Evaluation of the effect of midazolam sedation combined with fentanyl analgesia in children on ventilators
咪达唑仑镇静联合芬太尼镇痛对上呼吸机患儿的效果评价

摘要

目的 分析探讨对上呼吸机患儿实施咪达唑仑镇静联合芬太尼镇痛的效果。方法 本次选取研究对象均为机械通气患儿，共计142例，时间为2022年1月至2025年1月；研究采取对照实验形式进行，因此将142例患儿随机分配为2组，每组71例，分别为对照组、观察组，于对照组使用咪达唑仑镇静，观察组则实施咪达唑仑镇静、芬太尼镇痛联合应用，对比两组的镇静、镇痛效果。结果 观察组的心率、血压及Ramsay评分在用药后均优于对照组（P＜0.05）；观察组患儿用药后的N-PASS评分显著低于对照组（P＜0.05）；同时，观察组不良反应发生率明显低于对照组（P＜0.05）。结论 对机械通气患儿实施咪达唑仑镇静联合芬太尼镇痛可有效镇静、减轻疼痛并提高舒适度，对机械通气正常进行有重要帮助。

Abstract

Objective To analyze and explore the effect of midazolam sedation combined with fentanyl analgesia in children on ventilators.
Methods The research subjects selected for this study were all children with mechanical ventilation, a total of 142 cases, from January 2022 to January 2025. The study was conducted in the form of a controlled experiment, so 142 children were randomly assigned to 2 groups, each There were 71 cases in the group, which were divided into the control group and the observation group. The control group was given midazolam for sedation, while the observation group was given a combination of midazolam sedation and fentanyl analgesia. The sedation and analgesic effects of the two groups were compared.
Results The heart rate, blood pressure and Ramsay score of the observation group were better than those of the control group after medication (P<0.05); the N-PASS score of the children in the observation group after medication was significantly lower than that of the control group (P<0.05); at the same time, The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05).
Conclusion   Midazolam sedation combined with fentanyl analgesia can effectively sedate, reduce pain and improve comfort in children with mechanical ventilation, which is important for normal mechanical ventilation.