New progress in research on influencing factors and personalized treatment of patients with unexpected ovarian hyporesponsiveness
非预期卵巢低反应患者的影响因素及个体化治疗的研究新进展

摘要

非预期卵巢低反应是辅助生殖领域面临的重要挑战之一，本文对非预期卵巢低反应患者的影响因素及个体化治疗的研究新进展进行了探讨。在影响因素方面，患者自身因素、医源性因素以及其他因素均可能导致非预期卵巢低反应的发生。年龄增长与卵巢储备功能下降密切相关，遗传变异和基因多态性也在其中发挥作用；卵巢手术、化疗放疗对卵巢组织的损伤不可忽视，而心理压力和环境污染等也可能对卵巢功能产生潜在影响。个体化治疗方面，治疗前通过卵巢储备功能评估指标及预测模型对患者进行精准评估和预测。个体化促排卵方案不断优化，传统方案根据患者情况调整，新型促排卵药物和技术也逐渐应用。

Abstract

Unexpected ovarian hyporesponsiveness is one of the important challenges faced in the field of assisted reproduction. This article explores the influencing factors of patients with unexpected ovarian hyporesponsiveness and the new progress in personalized treatment research. In terms of influencing factors, patient factors, iatrogenic factors, and other factors may all lead to the occurrence of unexpected ovarian hyporesponsiveness. Aging is closely related to the decline of ovarian reserve function, and genetic variation and polymorphism also play a role in it; The damage to ovarian tissue caused by ovarian surgery, chemotherapy, and radiotherapy cannot be ignored, while psychological stress and environmental pollution may also have potential impacts on ovarian function. In terms of individualized treatment, patients are accurately evaluated and predicted through ovarian reserve function assessment indicators and prediction models before treatment. Individualized ovulation induction programs are constantly being optimized, traditional programs are adjusted according to patient conditions, and new ovulation induction drugs and technologies are gradually being applied.