Observation of the therapeutic effect of clopidogrel combined with aspirin in elderly patients with coronary heart disease in the community
社区老年冠心病患者中应用氯吡格雷联合阿司匹林实施治疗的效果观察

摘要

目的 观察分析社区老年冠心病患者，应用氯吡格雷联合阿司匹林实施治疗的效果。方法 本次观察时间起点为2023年6月1日，时间节点为2024年6月1日，观察对象为本社区的老年冠心病患者，将入选的100名患者随机分为观察组（n=50）与对照组（n=50），分别给予氯吡格雷联合阿司匹林、单一使用阿司匹林干预，将两组治疗效果进行统计对比。结果 治疗前两组患者血清因子水平和心功能无明显差异，治疗后观察组患者TNF-α、NT-proBNP、IL-6、hs-CRP水平低于对照组（P<0.05）。同时观察组患者的LVESD以及LVEDD水平比对照组患者更低，LVEF比对照组患者更高，对比分析差异明显（P＜0.05）。而且观察组患者的不良反应发生率更低（P＜0.05），用药安全性更好。结论 氯吡格雷联合阿司匹林治疗效果更为突出，可有效控制病情，降低血清因子水平，改善心功能，帮助社区老年冠心病患者获得最佳的预后。

Abstract

Objective To observe and analyze the effect of clopidogrel and aspirin in community elderly patients with coronary heart disease.
Methods the observation time starting point on June 1,2023, time node for June 1,2024, the observation object for the community of elderly patients with coronary heart disease, the selected 100 patients randomly divided into observation group (n=50) and the control group (n=50), respectively give clopidogrel combined aspirin, single use of aspirin intervention, the two groups of treatment effect.
Results There was no significant difference in serum factor levels and cardiac function between the two groups before treatment, and the levels of TNF- α, NT-proBNP, IL-6, and hs-CRP in the patients after treatment were lower than those in the control group (P <0.05). Lower LVESD and LVEDD levels and higher LVEF levels were also observed (P <0.05). Moreover, the observation group had a lower incidence of adverse reactions (P <0.05) and medication safety was better.
Conclusion   The treatment effect of clopidogrel combined with aspirin is more prominent, which can effectively control the disease, reduce the level of serum factors, improve cardiac function, and help the elderly patients with coronary heart disease in the community to obtain the best prognosis.