Clinical analysis of long-term hemoptysis with cavitary pulmonary tuberculosis complicated by fungal infection
长期空洞型肺结核合并真菌感染的临床分析

摘要

目的 研究长期咳血且肺部有空洞的肺结核患者合并真菌感染的临床特点。方法 选择我院于2023年1月-2024年1月内收治的50例长期咯血空洞型肺结核合并真菌感染患者为研究对象，分析肺结核伴随肺部真菌感染的临床表现及其相关因素。结果 50例患者中，反复咯血者占多数，伴有空洞形成及肺部真菌感染。其中，2例（4.00%）有一侧肺毁损，7例（14.00%）并发有少量胸腔积液。患者的病程长短、广谱抗生素使用时长、糖皮质激素治疗时间、以及治疗次数等因素为咯血空洞型肺结核合并真菌感染的影响因素，存在统计学上的显著差异（P<0.05）。结论 长期咯血空洞型肺结核合并肺部真菌感染受到病程长短、长时间使用广谱抗生素与糖皮质激素、以及肺结核复治等因素的影响。

Abstract

Objective Study the clinical characteristics of pulmonary tuberculosis patients with long-term hemoptysis and pulmonary cavities complicated by fungal infection.
Methods Select 50 patients with long-term hemoptysis cavitary pulmonary tuberculosis complicated with fungal infection admitted to our hospital from January 2023 to January 2024 as the research subjects, and analyze the clinical manifestations and related factors of pulmonary tuberculosis accompanied by fungal infection.
Results Among the 50 patients, the majority had recurrent hemoptysis, accompanied by cavity formation and pulmonary fungal infection. Among them, 2 cases (4.00%) had unilateral lung damage, and 7 cases (14.00%) had a small amount of pleural effusion. The duration of the patient's illness, the duration of broad-spectrum antibiotic use, the duration of glucocorticoid treatment, and the frequency of treatment are factors that affect the occurrence of fungal infection in hemoptysis cavitary pulmonary tuberculosis, with statistically significant differences (P<0.05).
Conclusion   Long term hemoptysis with cavitary pulmonary tuberculosis complicated by pulmonary fungal infection is influenced by factors such as the length of the disease course, long-term use of broad-spectrum antibiotics and glucocorticoids, and re treatment of pulmonary tuberculosis.