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当前位置：国际临床研究杂志 > 2025年 9卷 (3)期

Open Access Article

International Journal of Clinical Research. 2025; 9: (3) ; 45-50 ; DOI: 10.12208/j.ijcr.20250125.

Research progress on drug resistance characteristics and treatment of pathogenic bacteria in patients with diabetic foot infection
糖尿病足感染患者病原菌的耐药特征及其治疗的研究进展

作者： 何娟坤¹, 秦飞雪¹, 文斌¹, 刘师¹, 桂莉^1,2 *, 朱宏² *

1 大理大学临床医学院云南大理

2 云南省第三人民医院内分泌科云南昆明

*通讯作者：桂莉,单位：大理大学临床医学院云南大理；朱宏,单位：云南省第三人民医院内分泌科云南昆明；

发布时间: 2025-03-28 总浏览量: 71

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摘要

糖尿病足是糖尿病的严重并发症之一，给患者带来沉重负担。糖尿病足的发生与多种因素相关，包括神经病变、血管病变、感染和免疫功能低下等。而感染是引发足部坏疽、促使病情加剧的核心因素之一，采取切实有效的抗感染治疗是遏制病情恶化的关键举措。深入了解糖尿病足感染患者病原菌耐药特征并制定有效治疗策略至关重要。这有助于为患者制定个体化的治疗方案，从而提高治疗效果，降低截肢风险，改善患者预后与生活质量，同时也为合理使用抗菌药物、减少耐药菌的产生提供依据，在临床实践中具有重要的指导意义。本综述主要阐述目前国内外糖尿病足感染病原菌的耐药特征及其治疗的研究进展。

关键词： 糖尿病足感染；病原菌；耐药；治疗

Abstract

Diabetic foot is one of the serious complications of diabetes, which brings heavy burden to patients. The occurrence of diabetic foot is associated with many factors, including neuropathy, vascular disease, infection and immune dysfunction. Infection is one of the core factors that cause foot gangrene and aggravate the disease. Effective anti-infection treatment is the key measure to curb the deterioration of the disease. It is important to understand the characteristics of pathogen resistance in patients with diabetic foot infection and develop effective treatment strategies. It is helpful to develop an individualized treatment plan for patients, thereby improving the treatment effect, reducing the risk of amputation, improving the prognosis and quality of life of patients, and providing a basis for rational use of antibiotics and reducing the generation of drug-resistant bacteria, which has important guiding significance in clinical practice. This review mainly describes the current domestic and foreign research progress on drug resistance characteristics and treatment of pathogenic bacteria of diabetic foot infection.

Key words： Diabetic foot infection; Pathogenic bacteria; Drug resistance; Treatment

参考文献 References

[1] Noor S, Zubair M, Ahmad J. Diabetic foot ulcer--A review on pathophysiology, classification and microbial etiology [J]. Diabetes Metab Syndr, 2015, 9(3): 192-199.

[2] Ismail A A, Meheissen M A, Elaaty T a A, et al. Microbial profile, antimicrobial resistance, and molecular characterization of diabetic foot infections in a university hospital [J]. Germs, 2021, 11(1): 39-51.

[3] Shahrokh S, Aliye T, Yazdi M, et al. Bacterial Profile and Antimicrobial Resistance Patterns of Infected Diabetic Foot Ulcers in Iran: A Systematic Review and Meta-Analysis of Cross-Sectional Studies [J]. Int J Low Extrem Wounds, 2022, 21(4): 364-373.

[4] Nelson A, Wright-Hughes A, Backhouse M R, et al. CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England [J]. BMJ Open, 2018, 8(1): e019437.

[5] Du F, Ma J, Gong H, et al. Microbial Infection and Antibiotic Susceptibility of Diabetic Foot Ulcer in China: Literature Review [J]. Front Endocrinol (Lausanne), 2022, 13: 881659.

[6] 徐薇, 孙李永眷. 糖尿病足患者发生MDR感染的病原菌耐药性及其危险因素研究 [J]. 湖南师范大学学报(医学版), 2019, 16(05): 153-157.

[7] 袁红艳, 于楠, 王媛媛. 糖尿病足患者发生多重耐药菌感染的危险因素研究 [J]. 华南预防医学, 2021, 47(09): 1135 -1138.

[8] 徐斌, 李阳阳. 糖尿病足多重耐药菌感染的分布及耐药性的危险因素分析 [J]. 实用医院临床杂志, 2021, 18(04): 188-192.

[9] 朱伟雄, 方杭. 糖尿病足溃疡多重耐药菌感染的分布特点、耐药性及其危险因素分析 [J]. 中国卫生检验杂志, 2023, 33(02): 240-244.

[10] Liu X, Ren Q, Zhai Y, et al. Risk Factors for Multidrug-Resistant Organisms Infection in Diabetic Foot Ulcer [J]. Infect Drug Resist, 2022, 15: 1627-1635.

[11] Yan X, Song J F, Zhang L, et al. Analysis of risk factors for multidrug-resistant organisms in diabetic foot infection [J]. BMC Endocr Disord, 2022, 22(1): 46.

[12] Yang S, Hu L, Zhao Y, et al. Prevalence of multidrug-resistant bacterial infections in diabetic foot ulcers: A meta-analysis [J]. Int Wound J, 2024, 21(4): e14864.

[13] Sultana R, Ahmed I, Saima S, et al. Diabetic foot ulcer-a systematic review on relevant microbial etiology and antibiotic resistance in Asian countries [J]. Diabetes Metab Syndr, 2023, 17(6): 102783.

[14] Jouhar L, Jaafar R F, Nasreddine R, et al. Microbiological profile and antimicrobial resistance among diabetic foot infections in Lebanon [J]. Int Wound J, 2020, 17(6): 1764-1773.

[15] Saltoglu N, Surme S, Ezirmik E, et al. The Effects of Antimicrobial Resistance and the Compatibility of Initial Antibiotic Treatment on Clinical Outcomes in Patients With Diabetic Foot Infection [J]. Int J Low Extrem Wounds, 2023, 22(2): 283-290.

[16] 中华医学会糖尿病学分会, 中华医学会感染病学分会, 中华医学会组织修复与再生分会. 中国糖尿病足防治指南(2019版)(Ⅲ) [J]. 中华糖尿病杂志, 2019, 11(4): 238-247.

[17] 抗菌药物临床应用指导原则(2015版) [Z]. 2015年全国临床药师高峰论坛暨江西省医院药事管理学术年会论文集. 南昌. 2015: 1-7

[18] Gherardi G. Staphylococcus aureus Infection: Pathogenesis and Antimicrobial Resistance [J]. Int J Mol Sci, 2023, 24(9).

[19] Zhao H, Zhao S, Wang S, et al. Human β-defensins: The multi-functional natural peptide [J]. Biochem Pharmacol, 2024, 227: 116451.

[20] Breijyeh Z, Jubeh B, Karaman R. Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It [J]. Molecules, 2020, 25(6).

[21] Li W, Tao Z, Zhou M, et al. Antibiotic adjuvants against multidrug-resistant Gram-negative bacteria: important component of future antimicrobial therapy [J]. Microbiol Res, 2024, 287: 127842.

[22] Sun X J, Chen J A, Li G, et al. Maggot debridement therapy stimulates wound healing by altering macrophage activation [J]. Int Wound J, 2024, 21(3): e14477.

[23] Mathioudaki E, Vitsos A, Rallis M C. Proteolytic enzymes and wound debridement: a literature review [J]. Wounds, 2024, 36(11): 357-365.

[24] Liu C, Ling J, Yang L Y, et al. Chitosan-based carbon nitride-polydopamine‑silver composite dressing with antibacterial properties for wound healing [J]. Carbohydr Polym, 2023, 303: 120436.

[25] Cheng H, Shi Z, Yue K, et al. Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities [J]. Acta Biomater, 2021, 124: 219-232.

[26] Maleki A, He J, Bochani S, et al. Multifunctional Photoactive Hydrogels for Wound Healing Acceleration [J]. ACS Nano, 2021, 15(12): 18895-18930.

[27] Maranna H, Lal P, Mishra A, et al. Negative pressure wound therapy in grade 1 and 2 diabetic foot ulcers: A randomized controlled study [J]. Diabetes Metab Syndr, 2021, 15(1): 365-371.

[28] Mastrogiacomo M, Nardini M, Collina M C, et al. Innovative Cell and Platelet Rich Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach [J]. Front Bioeng Biotechnol, 2022, 10: 869408.

[29] Ouyang H, Tang Y, Yang F, et al. Platelet-rich plasma for the treatment of diabetic foot ulcer: a systematic review [J]. Front Endocrinol (Lausanne), 2023, 14: 1256081.

[30] Del Pino-Sedeño T, Trujillo-Martín M M, Andia I, et al. Platelet-rich plasma for the treatment of diabetic foot ulcers: A meta-analysis [J]. Wound Repair Regen, 2019, 27(2): 170-182.

[31] Gong F, Zhang Y, Gao J, et al. Effect of platelet-rich plasma vs standard management for the treatment of diabetic foot ulcer wounds: A meta-analysis [J]. Int Wound J, 2023, 20(1): 155-163.

[32] Kranke P, Bennett M H, Martyn-St James M, et al. Hyperbaric oxygen therapy for chronic wounds [J]. Cochrane Database Syst Rev, 2015, 2015(6): Cd004123.

[33] 中华医学会糖尿病学分会, 中华医学会感染病学分会, 中华医学会组织修复与再生分会. 中国糖尿病足防治指南(2019版)(Ⅰ) [J]. 中华糖尿病杂志, 2019, 11(2): 92-108.

引用本文

何娟坤, 秦飞雪, 文斌, 刘师, 桂莉, 朱宏, 糖尿病足感染患者病原菌的耐药特征及其治疗的研究进展[J]. 国际临床研究杂志, 2025; 9: (3) : 45-50.

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