Clinical analysis of glucocorticoids combined with immunosuppressants in the treatment of rheumatic renal diseases in children
糖皮质激素联合免疫抑制剂治疗儿童肾脏风湿性疾病的临床分析

摘要

目的 糖皮质激素联合免疫抑制剂治疗儿童肾脏风湿性疾病的临床分析。方法 实验收入样本均为我院2023年1月至2024年1月期间收治儿童肾脏风湿性疾病患儿，共计人数82例，以电脑随机分组方式作为标准，将参与者均分为两组，即对照组（免疫抑制剂治疗），观察组（糖皮质激素联合免疫抑制剂治疗），对实施过程中两组患儿相关指标数据作整理记录，结合统计学系统进行对比观察，分析糖皮质激素联合免疫抑制剂治疗干预应用价值。结果 观察组患儿C反应蛋白评分及，白介素-1评分及症状改善时间均低于另一组，总治疗有效率及生活质量数据相比另一组均呈现出较高优势性，组间对比P值﹤0.05，可见统计学意义。结论 儿童肾脏风湿性疾病患儿采取糖皮质激素联合免疫抑制剂治疗可明显缓解炎症反应，缩短改善时间，促进疗效提升，维护生活质量，整体效果确切，适合推广。

Abstract

Objective To analyze the clinical effect of glucocorticoids combined with immunosuppressants in the treatment of rheumatic renal diseases in children.
Methods The samples of the experiment were all children with rheumatic renal diseases admitted to our hospital from January 2023 to January 2024, with a total of 82 cases. The participants were divided into two groups by computer random grouping, namely the control group (immunosuppressant treatment) and the observation group (glucocorticoids combined with immunosuppressant treatment). The relevant index data of the two groups of children were sorted and recorded during the implementation process, and compared and observed with the statistical system to analyze the application value of glucocorticoids combined with immunosuppressants in the treatment intervention.
Results The C-reactive protein score, interleukin-1 score and symptom improvement time of the children in the observation group were lower than those of the other group. The total treatment efficiency and quality of life data showed a higher advantage than the other group. The inter-group comparison P value was ﹤0.05, which was statistically significant.
Conclusion   The combined use of glucocorticoids and immunosuppressants in children with rheumatic renal diseases can significantly relieve inflammatory responses, shorten the improvement time, promote the improvement of efficacy, and maintain the quality of life. The overall effect is definite and suitable for promotion.