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Open Access Article

International Journal of Clinical Research. 2024; 8: (12) ; 30-34 ; DOI: 10.12208/j.ijcr.20240506.

Research progress of TTLL12 in cancer
TTLL12在癌症中的研究进展

作者: 王艺润, 李雅冬 *

重庆医科大学附属第一医院颌面外科 重庆

*通讯作者: 李雅冬,单位:重庆医科大学附属第一医院颌面外科 重庆;

发布时间: 2024-12-25 总浏览量: 48

摘要

微管蛋白酪氨酸连接酶样类似物12(Tubulin-tyrosine ligase-like protein 12,TTLL12 )是微管蛋白酪氨酸连接酶家族(Tubulin tyrosine ligase-like family,TTLL)中的重要成员,共同负责微管蛋白的翻译后修饰,在癌症中的作用日益受到关注。TTLL12在多种癌症中的表达上调,并与不良预后相关。研究表明,TTLL12可能通过影响硝基化酪氨酸的形成,与人类癌症进展有关。TTLL12的异常表达可能通过干扰微管的正常功能,促进肿瘤细胞的生长和扩散。本综述旨在根据国内外现有研究总结TTLL12在多种癌症中的研究进展、生物学功能、及其可能的致癌机制,总结其作为潜在分子标志物和治疗靶点的可能性。TTLL12的深入研究可能为癌症的诊断、预后评估和治疗提供新的分子靶点,未来需要进一步探索TTLL12的具体作用机制,以及其在不同癌症中的表达模式和功能差异,以促进个体化治疗策略的发展。

关键词: TTLL12;微管蛋白;硝基酪氨酸;癌症;生物标志物

Abstract

Tubulin-tyrosine ligase-like protein 12 (TTLL12) is an important member of the tubulin tyrosine ligase family (TTLL), which is jointly responsible for the post-translational modification of tubulin and has received increasing attention for its role in cancer. TTLL12 is upregulated in a variety of cancers and is associated with poor prognosis. Studies have shown that TTLL12 may be associated with human cancer progression by affecting the formation of nitrotyrosine. Abnormal expression of TTLL12 may promote the growth and spread of tumor cells by interfering with the normal function of microtubules. This review aims to summarize the research progress, biological functions, and possible carcinogenic mechanisms of TTLL12 in various cancers based on existing studies at home and abroad, and summarize its possibility as a potential molecular marker and therapeutic target. In-depth research on TTLL12 may provide new molecular targets for cancer diagnosis, prognosis assessment and treatment. In the future, it is necessary to further explore the specific mechanism of action of TTLL12, as well as its expression pattern and functional differences in different cancers, to promote the development of personalized treatment strategies.

Key words: TTLL12; Microtubule protein; Nitrotyrosine; Cancer; Biomarker

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引用本文

王艺润, 李雅冬, TTLL12在癌症中的研究进展[J]. 国际临床研究杂志, 2024; 8: (12) : 30-34.