The effect of metronidazole combined with clindamycin regimen in the treatment of bacterial vaginitis
甲硝唑联合克林霉素方案用于细菌性阴道炎治疗的效果

摘要

目的 评估甲硝唑联合克林霉素疗法在细菌性阴道炎治疗中的有效性。方法 本研究纳入了我院2023年1月至2024年1月期间收治的100例确诊为细菌性阴道炎的患者作为分析对象，将其按随机分组方法分为对照组（50例，采取甲硝唑片治疗）和观察组（50例，在对照组基础上加用克林霉素治疗），对两组患者的相关临床指标、炎性因子（C-反应蛋白、白细胞介素-6）水平、降钙素原（PCT）水平、不良反应发生率以及复发率进行对比与评估。结果 观察组在阴道瘙痒缓解、白带恢复及症状改善时间上均显著短于对照组（P＜0.05），同时，观察组的C-反应蛋白、白细胞介素-6及降钙素原等炎症指标水平也明显低于对照组（P＜0.05），在不良反应发生率上，两组间无显著差异（P＞0.05），此外，观察组的复发率显著低于对照组（P＜0.05）。结论 针对细菌性阴道炎患者，采用了甲硝唑与克林霉素联合用药的治疗方案可获得更佳的治疗效果，显著改善患者炎性因子和降钙素原水平，降低复发率。在实际应用中展现出较高的价值，值得临床推广使用。

Abstract

Objective Evaluate the effectiveness of metronidazole combined with clindamycin therapy in the treatment of bacterial vaginitis.
Methods This study included 100 patients diagnosed with bacterial vaginitis admitted to our hospital from January 2023 to January 2024 as the analysis objects. They were randomly divided into a control group (50 cases, treated with metronidazole tablets) and an observation group (50 cases, treated with clindamycin in addition to the control group). The relevant clinical indicators, inflammatory factors (C-reactive protein, interleukin-6) levels, procalcitonin (PCT) levels, incidence of adverse reactions, and recurrence rates of the two groups of patients were compared and evaluated.
Results The observation group showed significantly shorter relief of vaginal itching, recovery of vaginal discharge, and improvement of symptoms compared to the control group (P<0.05). At the same time, the levels of inflammatory markers such as C-reactive protein, interleukin-6, and procalcitonin in the observation group were also significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). In addition, the recurrence rate in the observation group was significantly lower than that in the control group (P<0.05).
Conclusion   For patients with bacterial vaginitis, the combination therapy of metronidazole and clindamycin can achieve better therapeutic effects, significantly improve the levels of inflammatory factors and procalcitonin, and reduce the recurrence rate. It has demonstrated high value in practical applications and is worthy of clinical promotion and use.