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当前位置：国际临床研究杂志 > 2024年 8卷 (10)期

Open Access Article

International Journal of Clinical Research. 2024; 8: (10) ; 168-170 ; DOI: 10.12208/j.ijcr.20240439.

Research on the Association between Peripheral Blood Inflammatory Parameters and Pregnancy Outcome in Patients with IVF-ET
体外受精-胚胎移植患者外周血炎性指标对妊娠结局的影响

作者： 李娟 *, 盛佳佳, 张影, 唐志霞, 洪名云

合肥市妇幼保健院生殖中心安徽合肥

*通讯作者：李娟,单位：合肥市妇幼保健院生殖中心安徽合肥；

发布时间: 2024-10-29 总浏览量: 58

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摘要

目的探讨正常卵巢储备功能的不孕症患者在拮抗剂方案超促排卵周期中移植前外周血炎性指标水平对体外受精-胚胎移植（in vitro fertilization-embryo transfer，IVF-ET）妊娠结局的预测价值。方法回顾性分析2021年1月—2023年12月在我院生殖中心接受拮抗剂方案超促排卵且新鲜周期移植的168个周期的临床资料，分为妊娠组（83个周期）和未妊娠组（85个周期）。比较2组患者外周血炎性指标水平。利用多因素Logistic回归分析研究各指标对妊娠结局的预测价值。结果妊娠组NLR、PLR和SII均低于未妊娠组。多因素Logistic回归分析发现，高SII为影响妊娠结局的危险因素。结论对于卵巢储备功能正常且采用拮抗剂方案助孕的患者，SII对不良妊娠结局可能具有一定的预测价值。

关键词： 体外受精；胚胎移植；外周血炎性指标；妊娠结局

Abstract

Objective To explore the predictive value of inflammatory parameters in the peripheral blood before transplantation for IVF outcome in patients with normal ovarian reserve undergoing GnRH antagonist cycles.
Methods A retrospective analysis the clinical data including 168 women with normal ovarian reserve undergoing the GnRH antagonist cycles. They were divided into pregnancy group (n=83) and non-pregnancy group (n=85) . The inflammatory parameters in the peripheral blood were compared between the two groups. Logistic regression analysis was used to study the predictive value of each parameters on pregnancy outcome.
Results The NLR, PLR and SII of the non-pregnancy group were higher than that of the pregnancy group, (P＜0.05). Logistic regression analysis was found that SII was independent factors for pregnancy outcome in patients with IVF undergoing GnRH antagonist cycles.
Conclusion s For the patients with normal ovarian reserve undergoing GnRH antagonist cycles, SII has poor predictive value for adverse pregnancy outcome.

Key words： Fertilization in vitro; Embryo transfer; Peripheral blood inflammatory parameter; Pregnancy outcome

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引用本文

李娟, 盛佳佳, 张影, 唐志霞, 洪名云, 体外受精-胚胎移植患者外周血炎性指标对妊娠结局的影响[J]. 国际临床研究杂志, 2024; 8: (10) : 168-170.

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