Analysis of the Application of ALT and Lipemia Combined Testing in Blood Donor Initial Screening
丙氨酸氨基转移酶和脂血联合检测在献血者血液初筛中的应用分析

摘要

目的 分析丙氨酸氨基转移酶和脂血联合检测在献血者血液初筛中的应用效果。方法 选择我站2024年1月到2月共7260例无偿献血者，分别以干化学法ALT检测、湿式法ALT联合脂血检测方式进行分组，即为对照组（n=5045）、观察组（n=2215），将两组检测方式在献血者血液初筛中的应用效果进行分析。结果 观察组采用湿式法检测ALT与对照组采用干化学法检测都能够很好的显示献血者血液标本丙氨酸氨基转移酶的水平，两者在降低ALT报废率方面没有显著差异（P>0.05），但观察组能够联合检测脂血水平，实时反映献血者的血脂浓度情况，相比对照组有利于降低血液采集后的脂血报废率（P<0.05）。结论 干化学法和湿式法ALT初筛检验都能够较精准获得献血者的ALT水平,湿式法检测能够联合检测脂血水平，能够有效降低脂血的报废率，保证血液安全，避免资源浪费。

Abstract

Objective To analyze the application effect of combined detection of alanine aminotransferase and lipemia in the primary screening of blood donors.
Methods A total of 7260 voluntary blood donors in our station from January to February 2024 were selected and divided into groups using dry chemical method ALT detection and wet method ALT combined with lipemia detection, namely the control group (n=5045) and the observation group (n=5045). n=2215), the application effects of the two sets of detection methods in the primary screening of blood donors were analyzed.
Results The observation group used wet method to detect ALT and the control group used dry chemical method to detect the level of alanine aminotransferase in blood samples of blood donors. There was no significant difference between the two in reducing the ALT scrap rate (P> 0.05), but the observation group can jointly detect the lipemia level and reflect the blood lipid concentration of blood donors in real time. Compared with the control group, it is beneficial to reduce the lipemia scrap rate after blood collection (P<0.05).
Conclusion   Both dry chemical method and wet method ALT preliminary screening test can more accurately obtain the ALT level of blood donors. The wet method test can jointly detect the lipemia level, which can effectively reduce the scrap rate of lipemia, ensure blood safety, and avoid resource waste.