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Open Access Article

International Journal of Clinical Research. 2024; 8: (10) ; 46-50 ; DOI: 10.12208/j.ijcr.20240406.

Advances in dagliflozin in the treatment of type 2 diabetes mellitus
达格列净在2型糖尿病治疗中的研究进展

作者: 马平1 *, 付有娟2, 宿艳1, 王婷婷1, 高李川1, 马青青1, 张汝琪1

1 宁夏回族自治区中医医院暨中医研究院 宁夏银川

2 宁夏医科大学 宁夏银川

*通讯作者: 马平,单位: 宁夏回族自治区中医医院暨中医研究院 宁夏银川;

发布时间: 2024-10-29 总浏览量: 64

摘要

2型糖尿病是最常见的慢病之一。2型糖尿病主要通过口服药物和外源性胰岛素注释来控制血糖。肾近端小管中的钠-葡萄糖协同转运蛋白2 (SGLT2) 蛋白对葡萄糖再吸收起着重要作用。达格列净作为SGLT2的选择性抑制药,在治疗2型糖尿病中有很好的控糖作用和相对的安全性,被临床医生广泛运用。达格列净具有可以降低血压,保护心血管。本文对达格列净在2型糖尿病的治疗进展及作用机制进行了总结,以期为2型糖尿病患者的临床治疗和扩大达格列净适应证提供更多思路。

关键词: 达格列净;2型糖尿病

Abstract

Type 2 diabetes mellitus is one of the most common chronic diseases. Type 2 diabetes mellitus is mainly controlled by oral medications and exogenous insulin annotations. Sodium-glucose cotransporter protein 2 (SGLT2) protein in renal proximal tubules plays an important role in glucose reabsorption. Dagliflozin, as a selective inhibitor of SGLT2, is widely used by clinicians for the treatment of type 2 diabetes mellitus because of its excellent glycemic control and relative safety. Dagliflozin has the ability to lower blood pressure and protect cardiovascular. This article summarizes the therapeutic progress and mechanism of action of dagliflozin in type 2 diabetes mellitus, with a view to providing more ideas for the clinical treatment of type 2 diabetes mellitus patients and expanding the indications of dagliflozin.

Key words: Dagliflozin; type 2 diabetes mellitus

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引用本文

马平, 付有娟, 宿艳, 王婷婷, 高李川, 马青青, 张汝琪, 达格列净在2型糖尿病治疗中的研究进展[J]. 国际临床研究杂志, 2024; 8: (10) : 46-50.