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当前位置：国际临床研究杂志 > 2024年 8卷 (12)期

Open Access Article

International Journal of Clinical Research. 2024; 8: (12) ; 17-23 ; DOI: 10.12208/j.ijcr.20240504.

Observation on the clinical efficacy of modified Baitouweng decoction retention enema in the treatment of ulcerative colitis of damp-heat accumulation type under the theory of ' chronic disease entering collaterals
“久病入络”理论下白头翁汤加味保留灌肠治疗湿热蕴结型溃疡性结肠炎的临床疗效观察

作者： 梁国强, 吴婷婷, 孙宏文 *

南京中医药大学附属苏州市中医医院江苏苏州

*通讯作者：孙宏文,单位：南京中医药大学附属苏州市中医医院江苏苏州；

江苏省自然科学基金项目（BK20201179）江苏省中医流派研究院开放课题（JSZYLP2024004）苏州市科技计划项目（SKY2022015）苏州市卫生健康委员会重点病种诊疗技术项目（LCZX201817）苏州市科技发展计划（民生科技）关键技术项目（SS202082）苏州市吴门医派验方评价与转化重点实验室项目（szs2024031）苏州第九批姑苏卫生重点人才项目（编号：GSWS2023015）

发布时间: 2024-11-06 总浏览量: 17

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摘要

目的基于“久病入络”理论下，探讨湿热蕴结型溃疡性结肠炎患者临床治疗中使用白头翁汤加味保留灌肠治疗的临床效果。方法选取2022年1月-2023年11月我院收治的湿热蕴结型溃疡性结肠炎轻、中度活动期患者100例，按照治疗方式分为对照组（基础治疗+白头翁汤保留灌肠）和观察组（基础治疗+白头翁汤加味保留灌肠）各50例，对比两组治疗效果。结果治疗前两组患者中医症候积分、肠镜观察和血液理化指标等差异无统计学意义（P＞0.05），干预后观察组患者中医症候积分低于对照组，肠黏膜屏障修复和血液理化指标均优于对照组，差异均有统计学意义（P＜0.05）。结论临床中治疗湿热蕴结型溃疡性结肠炎轻、中度活动期患者使用白头翁汤加味保留灌肠结合口服美沙拉嗪肠溶片治疗能够显著改善患者血液理化指标和提高肠黏膜屏障愈合质量，增益性减轻临床症状，明显降低复发次数，具有较高临床推广应用价值。

关键词： 白头翁汤加味；湿热蕴结型；溃疡性结肠炎

Abstract

Objective To explore the clinical effect of modified Baitouweng decoction retention enema in the clinical treatment of patients with ulcerative colitis of damp-heat accumulation type based on the theory of ' chronic disease entering collaterals '.
Methods A total of 100 patients with mild and moderate active ulcerative colitis of damp-heat accumulation type admitted to our hospital from 2022.01 to 2023.11 were selected and divided into control group (basic treatment + Baitouweng decoction retention enema) and observation group (basic treatment + Baitouweng decoction retention enema) according to the treatment methods, with 50 cases in each group. The therapeutic effects of the two groups were compared.
Results There was no significant difference in TCM symptom score, colonoscopy observation and blood physical and chemical indexes between the two groups before treatment (P>0.05). After intervention, the TCM symptom score of the observation group was lower than that of the control group, and the intestinal mucosal barrier repair and blood physical and chemical indexes were better than those of the control group, with statistically significant differences (P< 0.05).
Conclusion In the clinical treatment of patients with mild and moderate active ulcerative colitis of damp-heat accumulation type, the use of Baitouweng Decoction retention enema combined with oral mesalazine enteric-coated tablets can significantly improve the patient 's blood physical and chemical indicators and improve the quality of intestinal mucosal barrier healing. The clinical symptoms are reduced and the number of recurrences is significantly reduced, which has a high clinical application value.

Key words： Modified Baitouweng Decoction; Accumulation of damp heat type; Ulcerative colitis

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引用本文

梁国强, 吴婷婷, 孙宏文, “久病入络”理论下白头翁汤加味保留灌肠治疗湿热蕴结型溃疡性结肠炎的临床疗效观察[J]. 国际临床研究杂志, 2024; 8: (12) : 17-23.

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