Clinical study of intravitreal injection of anti-VE GF drugs and retinal laser photocoagulation for diabetic retinopathy combined with macular oedema in DR patients in Samoa
萨摩亚DR患者玻璃体腔注射抗VEGF药物与视网膜激光光凝治疗糖尿病视网膜病变合并黄斑水肿的临床研究

摘要

目的 研究对萨摩亚地区糖尿病视网膜病变合并黄斑水肿患者在治疗中应用实施玻璃体腔注射抗VEGF药物与视网膜激光光凝治疗时所展现的临床实施效果与实施价值。方法 本次研究的病例数为128例，他们均来自于2024年1月-2024年6月期间萨摩亚TTM医院收治的糖尿病视网膜病变合并黄斑水肿患者，根据治疗方法的不同将所有患者分为对照组和观察组，其中对照组应用视网膜激光光凝术，观察组在对照组的基础上联合玻璃体腔注射抗VEGF药物治疗，并对两组患者的治疗效果、视网膜厚度、最佳矫正视力、眼压、SDF-1、VEGF、PDGF、CLVQOL以及并发症发生率进行对比分析。结果 经干预后观察组患者的治疗总有效率更高，差异具有统计学意义（P<0.05）；观察组患者的视网膜厚度、最佳矫正视力、眼压更好，差异具有统计学意义（P<0.05）；观察组患者的CLVQOL评分更高，差异具有统计学意义（P<0.05）；两组患者的并发症发生率无明显差异（P>0.05）。结论 对萨摩亚地区糖尿病视网膜病变合并黄斑水肿患者在治疗中联合玻璃体腔注射抗VEGF药物与视网膜激光光凝治疗的临床治疗效果优势明显，能够有效改善患者的视网膜厚度、最佳矫正视力、眼压和CLVQOL评分，值得在临床上进行推广。

Abstract

Objective: To study the clinical effect and implementation value of intravitreal injection of anti-VE GF drugs and retinal laser photocoagulation in patients with diabetic retinopathy complicated with macular edema in Samoa.
Methods: The number of cases in this study was 128, They were all from patients with diabetic retinopathy complicated with macular edema admitted to the TTM Hospital in Samoa between January 2024 and June 2024, All patients were divided into control and observation groups according to the different treatment methods, In which the control group applied retinal laser photocoagulation, The observation group was combined with intravitreal injection of anti-VE GF drugs based on the control group, And a comparative analysis of the treatment effect, retinal thickness, best corrected visual acuity, intraocular pressure, SDF-1, VE GF, PDGF, CLVQOL, and complication rate in both groups.
Results: After intervention, the overall response rate was higher and statistically significant (P <0.05); better retinal thickness, best corrected visual acuity, and IOP were statistically significant (P <0.05); higher CLVQOL score and statistically significant (P <0.05); and no significant difference in complication rate between the two groups (P> 0.05).
Conclusion  : The treatment of patients with diabetic retinopathy with macular edema combined with VE GF drugs and retinal laser photocoagulation has obvious advantages, which can effectively improve the retinal thickness, best corrected visual acuity, intraocular pressure and CLVQOL score, and is worth promoting in clinical practice.