The impact of massive blood transfusion on coagulation function in severely traumatized patients
大量输血对严重创伤患者凝血功能的影响

摘要

目的 探讨严重创伤患者大量输血治疗对其凝血功能的影响。方法 选取我院2022年7月~2023年7月内收治的需要输血的严重创伤患者74例，按照患者输血量分为对照组（少量输血治疗，输血量＜1600ml）和观察组（大量输血，输血量≥1600ml）各37例，对比两组治疗后凝血功能、免疫功能和不良反应。结果 输血前两组凝血功能差异无统计学意义（P＞0.05），治疗1d后观察组TT、PT、APTT均高于对照组，PLT低于对照组（P＜0.05），但Fbg差异不显著（P＞0.05）；治疗3d后观察组TT、PT均高于对照组（P＜0.05），APTT、PLT、Fbg差异不显著（P＞0.05）。但治疗前后两组免疫功能和不良反应发生率差异无统计学意义（P＞0.05）。结论 大量输血会对患者凝血功能产生一定影响，因此在对严重创伤患者进行输血治疗时，需要多方面评估，密切监测患者情况，以免发生凝血功能障碍。

Abstract

Objective: To explore the effect of massive blood transfusion therapy on coagulation function in patients with severe trauma. Method: A total of 56 severely injured patients who required blood transfusion and were admitted to our hospital from July 2022 to July 2023 were selected. They were divided into a control group (treated with a small amount of blood transfusion) and an observation group (treated with a large amount of blood transfusion) based on the amount of blood transfusion, with 28 patients in each group. The coagulation function, immune function, and adverse reactions of the two groups were compared after treatment. Result: There was no statistically significant difference in coagulation function between the two groups before treatment (P>0.05). After treatment, TT, PT, and APTT in the observation group were higher than those in the control group, while PLT and Fbg were lower than those in the control group, and the differences were statistically significant (P<0.05). However, there was no statistically significant difference in immune function and incidence of adverse reactions between the two groups before and after treatment (P>0.05).
Conclusion  : A large amount of blood transfusion can have a certain impact on the coagulation function of patients. Therefore, when performing blood transfusion therapy on severely traumatized patients, it is necessary to evaluate multiple aspects and closely monitor the patient's condition to avoid coagulation dysfunction.