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Open Access Article

International Journal of Clinical Research. 2024; 8: (9) ; 7-14 ; DOI: 10.12208/j.ijcr.20240340.

Research progress on liquid biopsy mainly based on circulating tumor cells in nasopharyngeal carcinoma
以循环肿瘤细胞为主的液体活检在鼻咽癌的研究进展

作者: 陈俐千琪1, 陈善义1,2 *

1暨南大学第二临床医学院 广东深圳

2深圳市人民医院放疗科 广东深圳

*通讯作者: 陈善义,单位:深圳市人民医院放疗科 广东深圳;

发布时间: 2024-09-21 总浏览量: 109

摘要

鼻咽癌是最常见的头颈部恶性肿瘤之一。近年来,随着治疗技术和治疗模式的不断发展,早期鼻咽癌患者5年生存率可达80%以上,但多数患者确诊时已是中晚期,因此,提高疗效、预测预后是降低局部复发和远处转移的重要手段。液体活检领域新起点—循环肿瘤细胞,是从原发肿瘤脱落并渗入到血液中循环的肿瘤细胞,作为一个提供实时关键分子信息的临床工具,可以根据个体患者肿瘤特征确定新治疗的方法、避免无效治疗的继续进行和防止非必要不良反应的发生,进一步加强癌症的管理和治疗。虽然液体活检在肿瘤领域有着令人瞩目的成果,但在国内鼻咽癌相关研究数据并不丰富。本文将集中于以循环肿瘤细胞为主的液体活检在鼻咽癌应用的最新进展和临床证据进行综述,并对未来的发展方向予以展望。

关键词: 循环肿瘤细胞;液体活检;鼻咽癌;疗效监测;预后预测

Abstract

Nasopharyal carcinoma is one of the most common head and neck tumors in China. In recent years, with the continuous development and progress of the treatment technology and treatment model, Early nasopharyngeal carcinoma patients can survive by more than 80%in 5 years. However, most patients are in the middle and late stages when diagnosis. Therefore, improving efficacy is an important means to reduce local recurrence and distant metastasis. Circulating tumor cells are tumor cells that detach from the primary tumor and infiltrate into the bloodstream. As a clinical tool that provides real-time key molecular information, they can determine new treatment methods based on individual patient tumor characteristics, avoid the continuation of ineffective treatment, and prevent unnecessary adverse reactions, further strengthening cancer management and treatment. Although liquid biopsy has achieved remarkable results in the field of tumors, there is not abundant research data related to nasopharyngeal carcinoma in China. This article will focus on the latest progress and clinical evidence of liquid biopsy mainly using circulating tumor cells in nasopharyngeal carcinoma, and provide prospects for future development.

Key words: Circular tumor cells; Liquid biopsy; Nasopharyal carcinoma; Efficacy monitoring; Prognostic prediction

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引用本文

陈俐千琪, 陈善义, 以循环肿瘤细胞为主的液体活检在鼻咽癌的研究进展[J]. 国际临床研究杂志, 2024; 8: (9) : 7-14.