摘要
目的 观察分析增生性瘢痕手术切除后注射透明质酸钠对抑制瘢痕再次增生的临床效果和应用价值。方法 前瞻性选取2023年1月-2023年12月期间在我科室治疗的60例增生性瘢痕手术切除患者，采取双盲法分别纳入实验组及对照组，对照组进行瘢痕切除后采用常规美容整形缝合，实验组将透明质酸钠注射液2mL注射于手术切口周围，再进行美容整形缝合。两组观察例数高度一致，收集分析治疗效果。结果 与对照组（常规美容整形缝合）相比，实验组（透明质酸导入）治疗后的VSS评分更低，VAS评分更低，ODI评分更低，（P<0.05）。结论 透明质酸导入可以有效促进增生性瘢痕手术切除患者恢复，缓解疼痛程度，改善术后功能康复情况，有较高应用价值。
关键词： 增生性瘢痕切除术；透明质酸导入；应用效果；瘢痕增生
Abstract
Objective: Observation and analysis of the clinical effect and application value of injecting sodium hyaluronate after surgical resection of hypertrophic scars to inhibit scar re proliferation. Method: A prospective selection of 60 patients with hypertrophic scar surgery who were treated in our department from January 2023 to December 2023 was conducted. They were included in the experimental group and the control group using a double-blind method. The control group underwent scar resection and conventional cosmetic plastic surgery suturing. The experimental group injected 2mL of sodium hyaluronate injection around the surgical incision, followed by cosmetic plastic surgery suturing. The number of observed cases in both groups is highly consistent, and the treatment effects are collected and analyzed. Result: Compared with the control group (conventional cosmetic surgery and suture), the experimental group (hyaluronic acid introduction) had lower VSS score, VAS score, and ODI score after treatment (P<0.05). Conclusion : Hyaluronic acid introduction can effectively promote the recovery of patients undergoing hypertrophic scar surgery, alleviate pain levels, and improve postoperative functional recovery, with high application value.
Key words： Hypertrophic scar resection surgery; Hyaluronic acid introduction; Application effect; Scar hyperplasia
参考文献 References
[1] 赵茜,马瑛.瘢痕注射联合手术切除激光治疗面部增生性瘢痕疗效及对VSS评分和瘙痒评分的影响[J].河北医学,2023,29(3):406-411.
[2] Jingjing C, Yan M, Yadan C, et al. Application and effect of tension-reducing suture in surgical treatment of hypertrophic scar[J]. BMC Surgery, 2024, 24(1): 119-119.
[3] 胡太平,陶剑光,李大鹏等.超声导入曲安奈德联合微等离子体射频技术对增生性瘢痕患者瘢痕组织学的影响[J].中国美容医学,2021,30(8):68-71.
[4] 龙丽芸.CO2点阵激光联合透明质酸导入治疗增生性瘢痕的临床效果[J].中国当代医药,2020,27(19):35-3741.
[5] 邹敬江,孙赛,陈容容等.透明质酸凝胶在非剥脱性点阵激光治疗面部凹陷性痤疮瘢痕后的修复效果观察[J].中国医药科学,2019,9(24):58-61.
[6] uJue W, LeMeng F, Cheng Z, et al. Anti-scarring effect of sodium hyaluronate at filtration pathway after filtering surgery in rabbits[J]. International journal of ophthalmology, 2022, 15(4):547-553.
[7] 林琳,宋俊红,陈立荣.透明质酸敷料联合超脉冲点阵CO_(2)激光对面部痤疮凹陷性瘢痕患者瘢痕修复情况及疼痛程度的影响[J].中国美容医学,2021,30(11):48-50
[8] 王一臣,蒋冠.胶原透明质酸敷料用于痤疮凹陷性瘢痕点阵铒激光术后的临床观察[J].徐州医科大学学报,2022,42(9):682-685
[9] 王玉英,俞舜,李京玲等.超脉冲CO_(2)点阵激光联合富血小板血浆和透明质酸凝胶治疗痤疮凹陷性瘢痕的疗效[J].中国医疗美容,2022,12(7):47-51
[10] Liu H ,Li H ,Wang J .Prevention effect of medical self-crosslinking sodium hyaluronate gel on epidural scar adhesion after laminectomy[J].Asian Pacific Journal of Tropical Medicine,2014,7(6):501-504.
[11] 许秋云,向妞.二氧化碳点阵激光联合透明质酸敷料治疗痤疮瘢痕的临床疗效分析[J].中国医疗美容,2021, 11(9):52-55.