Study on the effect of intermittent blue light irradiation combined with bifidobacterium tetrad tablet in the treatment of neonatal pathological jaundice
间歇蓝光照射联合双歧杆菌四联活菌片治疗新生儿病理性黄疸的效果研究

摘要

目的 探究间歇蓝光照射联合双歧杆菌四联活菌片治疗新生儿病理性黄疸的临床疗效及安全性。方法 研究纳入2023年2月-2024年3月我院收治的病理性黄疸新生儿患者80例，根据随机数表法分为对照组和试验组各40例。对照组予间歇蓝光照射治疗，试验组在对照组基础上联合应用双歧杆菌四联活菌片治疗，比较两组疗法的疗效及安全性。结果 治疗后，与对照组（80.00%）相比，试验组有效率（95.00%）显著增高，组间比较差异显著，P＜0.05。治疗后两组血清胆红素水平（TBil、Dbil、IBil）均有所下降，且试验组下降程度优于对照组，组间比较有统计学意义，P＜0.05。治疗后两组血清炎症指标（IL-6、IL-8与CRP）均有所下降，且试验组下降幅度优于对照组。治疗后两组患者肝功能相关酶指标（ALT、AST）均有所改善，且试验组改善程度明显优于对照组，组间比较P＜0.05，差异显著。而且治疗后不良反应发生率方面，两组都呈现较低水平，试验组（7.5%）与对照组（12.5%）无明显差异（P＞0.05）。结论 间歇蓝光照射联合双歧杆菌四联活菌片治疗新生儿病理性黄疸疗效确切，能够明显降低血清胆红素水平，改善炎症反应，保护患儿肝功能，且安全性良好。

Abstract

Objective To explore the clinical efficacy and safety of intermittent blue light irradiation combined with bifidobacterium tetrad tablets in the treatment of neonatal pathological jaundice.
Methods A total of 80 neonates with pathological jaundice admitted to our hospital from February 2023 to March 2024 were divided into control group and experimental group with 40 cases in each group according to random number table method. The control group was treated with intermittent blue light irradiation, and the experimental group was treated with bifidobacterium tetrad live tablets on the basis of the control group. The efficacy and safety of the two groups were compared.
Results After treatment, compared with the control group (80.00%), the effective rate of experimental group (95.00%) was significantly increased, and the difference between groups was significant (P < 0.05). After treatment, the serum bilirubin levels (TBil, Dbil, IBil) in both groups were decreased, and the reduction degree in the experimental group was better than that in the control group, with statistical significance (P < 0.05). After treatment, serum inflammatory indexes (IL-6, IL-8 and CRP) were decreased in both groups, and the decrease of experimental group was better than that of control group. After treatment, liver function related enzyme indexes (ALT, AST) were improved in both groups, and the improvement degree of the experimental group was significantly better than that of the control group, P < 0.05, the difference was significant. In addition, the incidence of adverse reactions after treatment was low in both groups, and there was no significant difference between the experimental group (7.5%) and the control group (12.5%) (P > 0.05).
Conclusion   Intermittent blue light irradiation combined with bifidobacterium tetrad active tablet is effective in the treatment of neonatal pathological jaundice, which can significantly reduce the level of serum bilirubin, improve the inflammatory response, protect the liver function of children with good safety.