CSCIED

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Clinical Research. 2024; 8: (7) ; 45-47 ; DOI: 10.12208/j.ijcr.20240251.

Current status of clinical application research on pentylethoxyquine hydrochloride
盐酸戊乙奎醚临床应用研究现状

作者: 张建升 *, 李伟东

佳木斯大学附属第一医院 黑龙江佳木斯

*通讯作者: 张建升,单位:佳木斯大学附属第一医院 黑龙江佳木斯;

发布时间: 2024-07-26 总浏览量: 534

摘要

盐酸戊乙金醚(penchyc lidine hydrochlor ide)是我国军事科学院自主研究的长效抗胆碱药,义名长托宁,化学结构为3-(2-环戊转-2-羟基-2-苯基乙氧基)。盐酸戊乙奎醚对M受体具有高度选择的作用,在抗胆碱及抑制腺体分泌方面发挥着高效而稳定的优势。在关于该药物临床应用的研究中,发现这一药物在多种疾病临床治疗中均展现出突出的应用价值。对此,本文中将收集整理有关盐酸戊乙奎醚临床应用的研究成果,对该药物的药代动力学与药效作用机制,以及该药物在各领域临床中实际应用的情况进行完整的论述,形成对这一药物临床应用发展更为全面的认知,为实际临床中该药物的推广应用以及后续相关课题研究提供更全面的理论参考资料。

关键词: 盐酸戊乙奎醚;临床应用;药代动力学;作用机制

Abstract

Penchyc lidine hydrochlor ide is a long-acting anticholinergic drug independently researched by Chinese Academy of Military Sciences. It is named Changtonin and has a chemical structure of 3- (2-cyclopentyl-2-hydroxy-2-phenylethoxy). Penehyclidine hydrochloride has a highly selective effect on M receptors, and plays an efficient and stable advantage in anticholine and inhibiting glandular secretion. In the study on the clinical application of this drug, it was found that this drug has shown outstanding application value in the clinical treatment of a variety of diseases. In this regard, this paper will collect and sort out the research results related to the clinical application of penehyclidine hydrochloride, and conduct a complete discussion on the pharmacokinetics and pharmacodynamic mechanism of this drug, as well as the actual clinical application of this drug in various fields, so as to form a more comprehensive understanding of the clinical application and development of this drug. To provide more comprehensive theoretical reference for the promotion and application of the drug in practice and the subsequent research on related topics.

Key words: Penehyclidine hydrochloride; Clinical application; Pharmacokinetics; Action mechanism

参考文献 References

[1] 李刚,何文胜,王凯,等.麻醉诱导前不同剂量盐酸戊乙奎醚对老年腹腔镜胆囊切除术患者氧化应激和血清S100β、NSE、BDNF的影响[J].现代生物医学进展,2024, 24(01):157-161.

[2] 黄德举.还原型谷胱甘肽联合盐酸戊乙奎醚治疗重度急性有机磷农药中毒患者的效果[J].中国民康医学,2023, 35(24):43-46.

[3] 高戈.盐酸戊乙奎醚与瑞芬太尼应用于老年麻醉的效果及VAS评分观察[J].婚育与健康,2023,29(06):58-60.

[4] 亢旭明,吴霜婷,倪坤强,等.术前雾化吸入盐酸戊乙奎醚对单肺通气时非通气侧肺损伤的影响及作用机制研究[J].中国临床新医学,2023,16(08):805-811.

[5] 朱安祥.盐酸戊乙奎醚抗缺血再灌注损伤的作用[J].临床荟萃,2012,27(12):1098-1100.

[6] 闵卫翔,张鹏,刘宇,等.盐酸戊乙奎醚不同给药途径对腹腔镜手术患者呼吸力学的影响[J].重庆医科大学学报,2022,47(06):740-744.

[7] 张强.持续性肾脏替代疗法联合盐酸戊乙奎醚、碘解磷定治疗急性重度有机磷中毒临床研究[J].实用中西医结合临床,2021,21(10):19-20.

[8] 胡乃元,欧阳华,徐巧精,等.盐酸戊乙奎醚预处理对失血性休克致急性肺损伤大鼠肺组织保护作用及对炎症因子的影响[J].中国老年学杂志,2023,43(01):124-128.

[9] 欧伙莲.盐酸戊乙奎醚对大鼠感染性休克肠黏膜细菌易位及血浆sIgA表达的影响[J].临床和实验医学杂志, 2017, 16(24): 2405-2408.

[10] 李水端,周福论,吴建平.不同剂量盐酸戊乙奎醚治疗急性有机磷农药中毒患者的临床效果分析[J].中外医疗, 2023, 42(35):85-88.

引用本文

张建升, 李伟东, 盐酸戊乙奎醚临床应用研究现状[J]. 国际临床研究杂志, 2024; 8: (7) : 45-47.