Effects of dexmedetomidine combined with oxeridine fumarate on recovery quality and hemodynamics of patients under general anesthesia during analgesic connection
右美托咪定联合富马酸奥赛立定用于镇痛衔接时对全身麻醉患者苏醒质量及血流动力学的影响

摘要

目的 浅析全身麻醉患者采用右美托咪定联合富马酸奥赛立定进行麻醉管理，稳定患者的血流动力学指标。方法 选取2023年1月至2023年12月收治的全身麻醉患者100例，对照组采用舒芬太尼作为镇痛衔接药物；观察组采用右美托咪定，富马酸奥赛立定作为镇痛衔接药物，对比临床护理效果。结果 观察组患者在拔管时间、苏醒时间以及意识恢复时间上，与对照组相比未见显著差异（P＞0.05）。但是在T2、T3、T4术后，观察组患者的心率和血压低于对照组，对比差异显著（P＜0.05）；此外，在对比患者的Ramsay镇静评分中，观察组患者术后1小时、6小时和12小时评分中，两组对比差异显著，在对比患者MMSE评分中，观察组总分高于对照组，对比差异显著（P＜0.05）。最后，患者的不良反应发生率对比差异较大（P＜0.05）。结论 全身麻醉患者在镇痛衔接时用右美托咪定，富马酸奥赛立定的效果显著，有助于稳定血流动力学指标，发挥镇痛作用，并防止苏醒期患者躁动，减少了术后恶心呕吐的发生率，预防不良反应发生，值得推广。

Abstract

Objective To analyze general anesthesia, dexmedetomidine combined with Orididine fumarate was used for anesthesia management to stabilize the hemodynamic index.
Methods 100 patients under general anesthesia from January 20232 to December 2023 were selected with sufentanil in the control group; dexmedetomidine and fumarate were used in the observation group to compare the clinical nursing effect.
Results There was no significant difference in extubation time, recovery time and consciousness recovery time in the control group (P> 0.05). However, after T2, T3 and T4, the heart rate and blood pressure of the observation group were lower than that of the control group (P <0.05); moreover, in the Ramsay sedation score of the comparison patients, the differences between the 1 hour, 6 hours and 12 hours after the observation group were significant, and in the MMSE score, the total score of the observation group was higher than that of the control group, and the comparison difference was significant (P <0.05). Finally, the incidence of adverse reactions in patients varied greatly (P <0.05).
Conclusion   Patients with general anesthesia use dexmedetomidine, and the effect of fumarate is remarkable, which helps to stabilize the hemodynamic indicators, play the analgesic effect, and prevent the agitation of patients in the awakening period, reduce the incidence of postoperative nausea and vomiting, and prevent the occurrence of adverse reactions, which is worth promoting.