Analysis of the clinical effect of tacrolimus combined with small-dose hormone therapy in IgA nephropathy
他克莫司联合小剂量激素治疗IgA肾病临床效果分析

摘要

目的 分析对IgA肾病患者采用他克莫司联合小剂量激素治疗的临床效果。方法 此次研究中病例抽取我医院收治的IgA肾病患者60例，将所有病例根据随机数字表法分成观察组与对照组各30例，对照组给予单独他克莫司治疗，观察组则添加小剂量激素治疗，对比两组治疗效果。结果 观察组患者的症状改善时间与对照组相比明显缩短，体内炎性因子水平以及肾功能改善效果均优于对照组，并发症发生率低于对照组，最终获得的治疗总有效率高于对照组，（P<0.05）。结论 对IgA肾病患者及时采用他克莫司与小剂量激素联合方案治疗，可使临床治疗效果得到进一步提升，短时间内改善患者的临床症状，降低体内炎性因子水平，减少并发症发生，减轻肾功能损伤程度，提高疾病控制效果。

Abstract

Objective To analyze the clinical effect of tacrolimus combined with low-dose hormone therapy in patients with IgA nephropathy.
Methods In this study, 60 cases of IgA nephropathy patients admitted to our hospital were selected, and all cases were divided into observation group and control group according to random number table method, 30 cases in each group. The control group was treated with tacrolimus alone, and the observation group was treated with small-dose hormone therapy. The therapeutic effect of the two groups was compared.
Results The improvement time of symptoms in the observation group was significantly shorter than that in the control group, the improvement effect of inflammatory factors and renal function was better than that in the control group, the complication rate was lower than that in the control group, and the total effective rate was higher than that in the control group (P<0.05).
Conclusion   The combination regimen of tacrolimus and low-dose hormone in IgA nephropathy patients can further improve the clinical treatment effect, improve the clinical symptoms of patients in a short time, reduce the level of inflammatory factors in the body, reduce the occurrence of complications, reduce the degree of renal damage, and improve the effect of disease control.