New progress in drug therapy for dry eye syndrome
干眼症药物治疗的研究新进展

摘要

作为临床中最常见的慢性眼表疾病，干眼症的特点是泪膜不稳定和眼表受损，这些问题与泪液质量、数量或动力学异常有关，进而导致眼睛感到不舒适。目前，干眼症的发病率正在逐渐上升，引起对其关注增加。传统治疗方法主要集中在通过替代泪液和最大限度地保持眼内泪液来缓解症状，而未能解决根本病因。随着对干眼症病理学认识的提高，已经提出了许多新的治疗方法。治疗干眼症的主要药物是人工泪液类滴眼液，辅助治疗可以采用非甾体类抗炎药和皮质类固醇，以缓解干眼症的不适。对于干眼症的长期用药，免疫抑制剂可作为一种有效选择。此外，自体血清和地夸磷索四钠也被广泛认可，有着良好的发展前景。

Abstract

As the most common chronic ocular surface disease in clinical practice, dry eye syndrome is characterized by unstable tear film and damage to the ocular surface, which are related to abnormal tear quality, quantity, or dynamics, leading to discomfort in the eyes. At present, the incidence rate of dry eye is gradually rising, causing increased attention to it. Traditional treatment methods mainly focus on relieving symptoms by replacing tears and maximizing the retention of intraocular tears, but fail to address the underlying causes. With the increasing understanding of the pathology of dry eye syndrome, many new treatment methods have been proposed. The main medication for treating dry eye syndrome is artificial tear eye drops, and auxiliary treatment can use non steroidal anti-inflammatory drugs and corticosteroids to alleviate discomfort in dry eye syndrome. Immunosuppressants can be an effective choice for long-term medication for dry eye syndrome. In addition, autologous serum and dexamethasone tetrasodium are widely recognized and have good development prospects.