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Open Access Article

International Journal of Clinical Research. 2024; 8: (6) ; 1-6 ; DOI: 10.12208/j.ijcr.20240195.

Research progress of lncRNA and colorectal cancer
lncRNA与结直肠癌的研究进展

作者: 张顺玲1, 郑盛2 *, 杨涓2

1 大理大学临床医学院 云南大理

2 大理大学第二附属医院 云南昆明

*通讯作者: 郑盛,单位: 大理大学第二附属医院 云南昆明;

发布时间: 2024-06-25 总浏览量: 393

摘要

近年来,越来越多的证据表明 lncRNA(long non-coding RNA,lncRNA)通过多种分子信号通路调节肿瘤增殖、凋亡、侵袭和转移等生物学过程。lncRNA在结直肠癌(colorectal cancer,CRC)中具有促癌及抑癌的双重作用,通过测定其表达量,可预测CRC患者的预后,但是相关文献报道较为零散,本文结合目前已有报道,就多种不同类型的lncRNA与CRC的研究进展作一综述。

关键词: 结直肠癌;大肠癌;lncRNAs;生物标志物;诊断;基因

Abstract

In recent years, more and more evidence has shown that lncRNA (long non-coding RNA) regulate biological processes such as tumor proliferation, apoptosis, invasion and metastasis through various molecular signaling pathways. LncRNA plays a dual role in promoting and suppressing cancer in colorectal cancer (CRC), and its expression level is used to predict the prognosis of CRC patients. However, relevant literature reports are scattered. Based on existing reports, this paper analyzes the role of lncRNA in colorectal cancer. This article reviews the research progress of various types of lncRNA and CRC.

Key words: Colorectal cancer; Long non-coding RNA; Biomarkers; Diagnosis; Gene

参考文献 References

[1] Patel S G, Karlitz J J, Yen T, et.al. The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection[J]. The Lancet Gastroenterology & Hepatology, 2022, 7(3): 262–274.

[2] Dekker E, Tanis P J, Vleugels J L A, et.al. Colorectal cancer[J]. The Lancet, 2019, 394(10207): 1467–1480.

[3] Pakarinen S, Varpe P, Carpelan A, et.al. Mobile-CEA – A Novel Surveillance Method for Patients with Colorectal Cancer[J]. Cancer Control,2022;29:10732748221102180.

[4] Selven H, Busund L-T R, Andersen S, et.al. High expression of microRNA-126 relates to favorable prognosis for colon cancer patients[J]. Scientific Reports, 2021, 11(1): 9592.

[5] Wang Y, Lu J-H, Wu Q-N, et.al. LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer[J]. Molecular Cancer, 2019, 18(1): 174.

[6] Li J, Liu C. Coding or Noncoding, the Converging Concepts of RNAs[J]. Frontiers in Genetics, 2019, 10: 496.

[7] Wang L, Cho K B, Li Y, et.al. Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer[J]. International Journal of Molecular Sciences, 2019, 20(22): 5758.

[8] Liang R, Zhi Y, Zheng G, et.al. Analysis of long non-coding RNAs in glioblastoma for prognosis prediction using weighted gene co-expression network analysis, Cox regression, and L1-LASSO penalization[J]. OncoTargets and Therapy, 2018;12:157-168.

[9] Fagerberg L, Hallström B M, Oksvold P, et.al. Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics[J]. Molecular & Cellular Proteomics, 2014, 13(2): 397–406.

[10] Xue D, Xue YF, Zhang LJ, Cui LZ, Guo KQ, Lian J. LINC00641 induces the malignant progression of colorectal carcinoma through the miRNA-424-5p/PLSCR4 feedback loop. Eur Rev Med Pharmacol Sci. 2021;25(2):749-757.

[11] Hong Z, Pan J, Chen M, et.al. Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis[J]. Z. Kang. Journal of Oncology, 2022, 2022: 1–16.

[12] Ni T, Li Y, Guo D, Tan L, Xiao Z, Shi Y. LncRNA DNAJC3-AS1 promotes the biological functions of papillary thyroid carcinoma via regulating the microRNA-27a-3p/CCBE1 axis. Cell Biol Int. 2023;47(3):539-547. 

[13] Tang Y, Tang R, Tang M, et.al. LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer[J]. Frontiers in Oncology, 2021, 10: 604534.

[14] 曹志军,张智伟,李志国, 李硕.长链非编码RNA DNAJC3-AS1、微RNA-214-3p在结肠癌组织、结肠腺瘤性息肉中的表达水平及临床意义[J]. 安徽医药, 2024, 28(02):  366-370.

[15] Han B, Ge Y, Cui J, et.al. Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis[J]. Bioengineered, 2020, 11(1): 524–535.

[16] Pal G, Ogunwobi O O. Copy number-based quantification assay for non-invasive detection of PVT1-derived transcripts[J]. D. Nie. PLOS ONE, 2019, 14(12): e0226620.

[17] Martínez-Barriocanal Á, Arango D, Dopeso H. PVT1 Long Non-coding RNA in Gastrointestinal Cancer. Front Oncol. 2020,10(38).

[18] Mai S, Zhang Z, Mi W. Upregulation of circ_PVT1 and circ_001569 Indicate Unfavorable Prognosis in Colorectal Cancer[J]. 2021, 51(1).

[19] 李韵, 金子慧, 张瑞瑞, et.al. 环状RNA PVT1促进结直肠癌细胞的增殖并抑制凋亡[J]. 中国生物化学与分子生物学报, 2021, 37(9): 1241–1249.

[20] Zeng X, Liu Y, Zhu H, et.al. Downregulation of miR-216a-5p by long noncoding RNA PVT1 suppresses colorectal cancer progression via modulation of YBX1 expression[J]. Cancer Management and Research, 2019;11:6981-6993. 

[21] Guo H, Zhuang K, Ding N, et.al. High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer[J]. Cell Death & Disease, 2022, 13(10): 883.

[22] Zhang M, Wang W, Li T, et al. Long noncoding RNA SNHG1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis. Biomed Pharmacother. 2016;80:73-79.

[23] Xu Y, Bao Y, Qiu G, et.al. METTL3 promotes proliferation and migration of colorectal cancer cells by increasing SNHG1 stability[J]. Molecular Medicine Reports, 2023, 28(5): 217.

[24] Bai J, Xu J, Zhao J, et.al. lncRNA SNHG1 cooperated with miR‐497/miR‐195‐5p to modify epithelial–mesenchymal transition underlying colorectal cancer exacerbation[J]. Journal of Cellular Physiology, 2020, 235(2): 1453–1468.

[25] Huang Q, Yang Z, Tian JH, et al. LncSNHG1 Promoted CRC Proliferation through the miR-181b-5p/SMAD2 Axis. J Oncol. 2022;2022:4181730.

[26] 曹强.长链非编码RNA SNHG1对结直肠癌增殖、迁移的影响及调控机制[J].黑龙江医学,2024,48(04):403-406.

[27] Shen W, Yu Q, Pu Y, Xing C. Upregulation of Long Noncoding RNA MALAT1 in Colorectal Cancer Promotes Radioresistance and Aggressive Malignance. Int J Gen Med. 2022;15:8365-8380.

[28] Yang F, Gong S, Qiu D. Circ‐ MALAT1 accelerates cell proliferation and epithelial mesenchymal transformation of colorectal cancer through regulating MIR ‐506‐3p/ KAT6B axis[J]. The Kaohsiung Journal of Medical Sciences, 2023, 39(9): 862–872.

[29] Cao L, Yan G, Yu S, et al. Associations of MALAT1 and its functional single nucleotide polymorphisms with cancer. Pathol Res Pract. 2022;236:153988.

[30] Xu J, Xiao Y, Liu B, et al. Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway. J Exp Clin Cancer Res. 2020;39(1):54.

[31] Ghafouri-Fard S, Kamali M J, Abak A, et.al. LncRNA ZFAS1: Role in tumorigenesis and other diseases[J]. Biomedicine & Pharmacotherapy, 2021, 142: 111999.

[32] O’Brien S J, Fiechter C, Burton J, et.al. Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma[J]. Cell Death Discovery, 2021, 7(1): 61.

[33] Deng H, Wang M, Xu Q, et.al. ZFAS1 Promotes Colorectal Cancer Metastasis Through Modulating miR-34b/SOX4 Targeting[J]. Cell Biochemistry and Biophysics, 2021, 79(2): 387–396.

[34] Wang H, Chen Y, Liu Y, et.al. The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA[J]. Molecular Therapy - Nucleic Acids, 2022, 27: 363–374.

[35] Zhang L, Yang J, Luo Y, et.al. A p53/lnc‐Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance[J]. Advanced Science, 2020, 7(21): 2001364.

[36] Zhang L, Zhang J, Xuan X, et.al. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression[J]. Cell Reports, 2023, 42(8): 112833.

[37] Ni X,Xie JK,Wang H,Song HR. Knockdown of long non-coding RNA LINC00324 inhibits proliferation, migration and invasion of colorectal cancer cell via targeting miR-214-3p[J] Eur Rew Med Pharmacol Sci. 2019;23(24):10740-10750.

[38] Gong X, Ning B. Five lncRNAs Associated With Prostate Cancer Prognosis Identified by Coexpression Network Analysis[J]. Technology in Cancer Research & Treatment, 2020, 19: 153303382096357.

[39] Liu Y, Yang B, Su Y, et.al. Downregulation of long noncoding RNA LINC00683 associated with unfavorable prognosis in prostate cancer based on TCGA[J]. Journal of Cellular Biochemistry, 2019, 120(8): 14165–14174.

[40] Pan H, Yu T, Sun L, et.al. LncRNA FENDRR-mediated tumor suppression and tumor-immune microenvironment changes in non-small cell lung cancer[J]. Translational Cancer Research, 2020, 9(6): 3946–3959.

[41] Yin S L, Xiao F, Liu Y F, et.al. Long non‐coding RNA FENDRR restrains the aggressiveness of CRC via regulating miR‐18a‐5p/ING4 axis[J]. Journal of Cellular Biochemistry, 2020, 121(8–9): 3973–3985.

[42] Cheng C, Li H, Zheng J, et.al. FENDRR Sponges miR-424-5p to Inhibit Cell Proliferation, Migration and Invasion in Colorectal Cancer[J]. Technology in Cancer Research & Treatment, 2020, 19: 153303382098010.

[43] Gong F, Dong D, Zhang T, et.al. Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR[J]. European Journal of Pharmacology, 2019, 853: 345–352.

[44] Zhang Q, Ding Z, Wan L, et.al. Comprehensive analysis of the long noncoding RNA expression profile and construction of the lncRNA-mRNA co-expression network in colorectal cancer[J]. Cancer Biology & Therapy, 2020, 21(2): 157–169.

[45] Shen Y, Qi L, Li Y, et.al. The Downregulation of lncRNA pgm5-as1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer[J]. Cancer Biotherapy and Radiopharmaceuticals, 2021, 36(2): 220–229.

[46] Zhou B, Yi F, Chen Y. Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p[J] .Eur Rew Med Pharmacol Sci.2020;24(15):7972-7981.

[47] Wang M, Zhang Z, Pan D, et.al. Circulating lncRNA UCA1 and lncRNA PGM5-AS1 act as potential diagnostic biomarkers for early-stage colorectal cancer[J]. Bioscience Reports, 2021, 41(7): BSR20211115.

[48] Stamou M, Ng S-Y, Brand H, et.al. A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator[J]. The Journal of Clinical Endocrinology & Metabolism, 2020, 105(3): e231–e244.

[49] Chen S, Ji L, Wang Y, et.al. lncRNA RMST suppresses the progression of colorectal cancer by competitively binding to miR-27a-3p/RXRα axis and inactivating Wnt signaling pathway[J] . 2023;55(5):726-735.

引用本文

张顺玲, 郑盛, 杨涓, lncRNA与结直肠癌的研究进展[J]. 国际临床研究杂志, 2024; 8: (6) : 1-6.