Clinical analysis of apatinib combined with radiotherapy and chemotherapy in the treatmentof adult brainstem gliomas
阿帕替尼联合放化疗治疗成人脑干胶质瘤的临床分析

摘要

目的 探讨阿帕替尼与放化疗联合应用在成人脑干胶质瘤治疗中的应用价值。方法 筛选2022年1月-2023年1月本院48例成人脑干胶质瘤患者实施分组研究，以电脑随机抽签法为分组方式，组别设置为对照组与研究组，每组各24例。对照组接受放化疗治疗，研究组增加阿帕替尼治疗，从近期疗效、治疗前后免疫功能变化、治疗后生活情况与精神状态三个方面综合评价阿帕替尼联合放化疗治疗效果。结果 两组患者客观缓解率对比，研究组（65.50%）高于对照组（45.83%），经χ2验证，组间差异显著（P＜0.05）；治疗前，对比两组患者各免疫指标并无显著性差异（P＞0.05），治疗后，对照组CD3＋、CD4＋ 、CD4＋/CD8＋低于研究组（P＜0.05）；两组患者KPS、MMSE评分对比，经t验证，组间差异显著（P＜0.05），研究组均高于对照组。结论 阿帕替尼联合放化疗治疗成人脑干胶质瘤效果显著，对患者生活质量、精神状态改善有重要价值，临床需结合患者情况灵活应用。

Abstract

Objective To investigate the application value of Apatinib combined with chemoradiotherapy in the treatment of adult brain stem glioma.
Methods From January 2022 to January 2023, 48 adult patients with brain stem glioma in our hospital were selected and grouped into control group and study group by computer random drawing method, with 24 cases in each group. The control group received radiotherapy and chemotherapy, while the study group received apatinib treatment. The effect of Apatinib combined with radiotherapy and chemotherapy was comprehensively evaluated from three aspects: short-term efficacy, changes in immune function before and after treatment, life conditions after treatment and mental state.
Results The objective response rate of the two groups was higher in the study group (65.50%) than in the control group (45.83%), and the difference was significant by χ2 test (P < 0.05). Before treatment, there was no significant difference in immune indexes between the two groups (P > 0.05). After treatment, CD3+, CD4+, CD4+/CD8+ in the control group were lower than those in the study group (P < 0.05). The KPS and MMSE scores of the two groups were compared, and the difference between the two groups was significant (P < 0.05), and the study group was higher than the control group.
Conclusion   Apatinib combined with chemoradiotherapy is effective in the treatment of adult brain stem glioma, which is of great value in improving the quality of life and mental state of patients.