摘要
目的 探究德谷门冬双胰岛素注射液治疗2型糖尿病临床效果及安全性。方法 选取2022年3月-2023年3月收治的90例2型糖尿病患者作为研究对象,将其分为两组,其中对照组(二甲双胍片口服),试验组(二甲双胍口服+德谷门冬双胰岛素注射液治疗),对比两组患者的相关指标。结果 试验组患者的临床疗效、糖代谢指标、血脂指标以及胰岛功能水平均优于对照组,组间差异明显(P<0.05);同时,试验组患者的安全性更高(P<0.05)。结论 通过应用德谷门冬双胰岛素注射液治疗,能够有效改善2型糖尿病患者的各项指标,有着较为确切的临床疗效,且安全性高,值得推广。
关键词: 德谷门冬双胰岛素注射液;2型糖尿病;临床效果;安全性
Abstract
Objective To explore the clinical effect and safety of Degu aspart double insulin injection in the treatment of type 2 diabetes mellitus. Methods 90 patients with type 2 diabetes treated from March 2022 to March 2023 were selected as research objects and divided into two groups, including control group (oral metformin tablet) and experimental group (oral metformin + dextral asparton double insulin injection treatment), and the relevant indicators of the two groups were compared. Results The clinical efficacy, glucose metabolism index, lipid index and islet function level of experimental group were better than those of control group, and the differences between groups were significant (P<0.05). At the same time, the safety of experimental group was higher (P<0.05). Conclusion The application of Degu aspartic double insulin injection can effectively improve the various indicators of type 2 diabetes patients, and has a relatively accurate clinical efficacy, high safety, worthy of promotion.
Key words: Degu aspartate injection; Type 2 diabetes; Clinical effect; security
参考文献 References
[1] 曹亮,田皎丁,杨娜,等.针刺联合大黄䗪虫汤加味治疗糖尿病周围神经病变临床研究[J].陕西中医,2021,42(8): 1120-1123.
[2] 冰清.胰岛素泵持续皮下注射联合二甲双胍治疗妊娠期糖尿病的临床效果及对其糖脂代谢与母婴结局的影响[J].临床合理用药杂志,2021,14(35):7-9.
[3] 李海燕.重组甘精胰岛素联合阿卡波糖治疗门冬胰岛素30对2型糖尿病血糖控制不佳的应用效果评价[J].中国药物与临床,2022,22(1):69-71.
[4] 王芳旭,张磊,陶立波.德谷门冬双胰岛素对比甘精胰岛素治疗口服降糖药控制不佳的中国2型糖尿病患者的成本-效果[J].中国药物经济学,2020,15(7):24-30.
[5] 宋玉莲,薛冀苏,陈慧,等.德谷门冬双胰岛素治疗2型糖尿病的短期疗效观察[J].兰州大学学报:医学版,2022, 48(2):37-41.
[6] Hompesch M, Patel DK, LaSalle JR, et al. Pharmacokinetic and pharmacodynamic differences of new generation, longer-acting basal insulins: potential implications for clinical practice in type 2 diabetes[J]. Postgraduate Medicine, 2019, 131(2): 117-128.
[7] 刘舒,苏珂.优泌乐50与甘精胰岛素治疗口服降糖药血糖控制不佳的2型糖尿病患者的效果比较[J].实用临床医药杂志,2018,22(15):44-46.
[8] 翟小方,李惠琴,苏晓飞,等.应用动态血糖监测评价甘精胰岛素治疗2型糖尿病患者血糖控制的研究[J].中国糖尿病杂志,2020,28(4):272-275.
[9] 张菁,姚蔚,张进安,等.沙格列汀联合前列地尔治疗老年糖尿病肾病临床评价[J].陕西医学杂志,2020,49(12): 1657-1660.
[10] 时永强,丁燕,丁丽萍.无针注射甘精胰岛素对2型糖尿病的控糖效果及胰岛β细胞功能的影响[J].重庆医学,2021,50(22):3883-3886,3891.
[11] 李萌,林矗,罗樱樱,等.胰岛素强化治疗后转换为德谷门冬双胰岛素治疗新诊断糖尿病一例[J].中华糖尿病杂志,2021,13(Z1):1-4.
[12] Glastras SJ, Cohen N, Dover T, et al. The clinical role of insulin degludec/insulin aspart in type 2 diabetes: an empirical perspective from experience in Australia[J]. Journal of Clinical Medicine, 2020, 9(4): 1091-1099.
[13] 杜喜维,吴娟,孙宝,等.门冬胰岛素联合甘精胰岛素对新诊断2型糖尿病患者炎性因子、血糖及血脂水平的影响[J].现代生物医学进展,2020,20(12):2342-2345.
[14] 朱大龙,赵维纲,匡洪宇,等.德谷门冬双胰岛素临床应用专家指导意见[J].中华糖尿病杂志,2021,13(7):695-701.
[15] 涂晶晶,唐建东,张维,等.达格列净联合甘精胰岛素及门冬胰岛素对2型糖尿病血糖控制不佳患者血糖波动的影响[J].中国老年学杂志,2020,40(10):2044-2047.
[16] 尹东,杜丽坤.德谷门冬双胰岛素治疗2型糖尿病合并肾上腺腺瘤导致库欣综合征一例的临床体会[J].中华糖尿病杂志,2021,13(Z1):20-22.
[17] 王昕,杨文英,马建华,等.2型糖尿病患者每日两次德谷门冬双胰岛素或双时相门冬胰岛素30治疗的糖化血红蛋白达标预测因子—德谷门冬双胰岛素中国Ⅲ期临床注册研究事后分析[J].中国糖尿病杂志,2021,29(10):742-748.