The effect of low-dose spironolactone in elderly patients with refractory hypertension
小剂量螺内酯在老年难治性高血压患者中的效果

摘要

目的 探讨小剂量螺内酯在老年难治性高血压患者中的效果。方法 选择2022年4月到2023年4月收治的老年难治性高血压患者48例作为研究对象，将其按照随机数字表法分为对照组（n=24例，实施常规治疗）与实验组（n=24例，实施小剂量螺内酯治疗）。对比两组血压水平以及生活质量。结果 实验组收缩压、舒张压显著下降，均低于对照组，差异有统计学意义（P＜0.05）；实验组生活质量高于对照组，差异有统计学意义（P＜0.05）。结论 小剂量螺内酯在老年难治性高血压患者中能够有效降低患者血压，提高患者生活质量，具有推广价值。

Abstract

Objective To explore the effect of low-dose spironolactone in elderly patients with refractory hypertension.
Methods 48 elderly patients with refractory hypertension admitted from April 2022 to April 2023 were selected as the study subjects. They were randomly divided into a control group (n=24 cases, receiving conventional treatment) and an experimental group (n=24 cases, receiving low-dose spironolactone treatment) using a random number table method. Compare blood pressure levels and quality of life between two groups.
Results The systolic and diastolic blood pressure in the experimental group significantly decreased, both lower than those in the control group, and the difference was statistically significant (P<0.05); The quality of life in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05).
Conclusion   Low dose spironolactone can effectively reduce blood pressure and improve quality of life in elderly patients with refractory hypertension, and has promotional value.