Research progress on the role of cytokines in the pathogenesis of diabetes retinopathy
细胞因子在糖尿病视网膜病变发病中的作用研究进展

摘要

糖尿病，作为一种代谢性疾病，其主要症状为高血糖。糖尿病视网膜病变（DR），即糖尿病所引发的眼部慢性微血管炎症病变，其生成根源在于眼内血管长时间处于高血糖状态，导致氧化还原平衡失调、氧化应激以及慢性轻度炎症反应等问题，DR被视为糖尿病较为严重的并发症之一。目前，糖尿病（DM）在中国的患病比例持续增长，同时DR的发病比例也在持续攀升，已经成为中国最高的失明眼病。DR的形成过程极为复杂，是一种由多种因素引起的逐渐恶化的疾病，尽管目前对于DR具体形成原理尚不明确，但有相关研究指出，细胞因子和DR的形成和演变存在某种程度的相互影响。为深化细胞因子对DR影响的理解，本文将对炎症指数、血管增殖相关因子以及趋化因子等与DR之间的关联进行深入探讨，以期为糖尿病视网膜病变的研究提供理论依据。

Abstract

Diabetes, as a metabolic disease, its main symptom is hyperglycemia. Diabetic retinopathy (DR) is the chronic ocular microvascular inflammation caused by diabetes. The root cause of DR is that the blood vessels in the eye are in a state of hyperglycemia for a long time, leading to REDOX imbalance, oxidative stress and chronic mild inflammatory reaction, etc. Dr is regarded as one of the more serious complications of diabetes. At present, the prevalence of diabetes mellitus (DM) in China continues to increase, while the incidence of DR Continues to rise, and has become the highest blind eye disease in China. The formation process of DR is extremely complex, which is a gradually worsening disease caused by a variety of factors. Although the specific formation principle of DR is not clear at present, relevant studies have pointed out that there is a certain degree of interaction between cytokines and the formation and evolution of DR. In order to deepen the understanding of the influence of cytokines on DR, the correlation between inflammatory index, vascular proliferation-related factors and chemokines and DR will be deeply discussed in this paper, in order to provide a theoretical basis for the study of diabetic retinopathy.