Clinical observation on the clinical effect of Quzhuohuayu Powder in treating acute gouty arthritiswith dampness-heat obstruction
自拟祛浊化瘀散外治急性痛风性关节炎湿热痹阻型临床疗效观察

摘要

目的 探究自拟祛浊化瘀散外治急性痛风性关节炎湿热痹阻型临床疗效。方法 选取我院2023年1月～2024年1月收治的60例湿热痹阻证痛风性关节炎患者，分组-双盲法，分为XY组与ZN组，两组各30例，XY组、ZN组分别采用常规西药治疗、自拟祛浊化瘀散。比较两组膝关节功能（Lysholm评分）、疼痛情况（VAS评分）、C反应蛋白、尿酸、膝关节活动度、疼痛指数、畸形程度。结果 ①Lysholm评分、VAS评分：治疗前两组患者无明显差异（t=0.020、0.099，P＞0.05），治疗后ZN组Lysholm评分更高，VAS评分更低（P＜0.05）；②C反应蛋白、尿酸：治疗前两组患者无显著差异（P＞0.05），治疗后ZN组更低（P＜0.05）；③膝关节活动度、疼痛指数、畸形程度：治疗前，两组患者无显著差异（P＞0.05），治疗后ZN组患者膝关节活动度更高，疼痛指数、畸形程度评分更低（t=16.547、9.798、6.407，P＜0.05）。结论 在急性痛风性关节炎湿热痹阻型患者治疗中采用自拟祛浊化瘀散外治干预能有效改善患者膝关节功能，降低其疼痛水平，改善炎性因子水平，并提升其膝关节活动度，降低其关节畸形程度，值得推广实施。

Abstract

Objective To explore the clinical efficacy of self-designed Quzhuo Huayu San in the external treatment of acute gouty arthritis with damp heat obstruction type.
Methods Sixty patients with gouty arthritis of damp heat obstruction syndrome admitted to our hospital from January 2023 to January 2024 were selected and divided into XY group and Zn group using a double-blind method, with 30 cases in each group. The XY group and Zn group were treated with conventional Western medicine and self formulated Quzhuo Huayu powder, respectively. Compare the knee joint function (Lysholm score), pain status (VAS score), C-reactive protein, uric acid, knee range of motion, pain index, and degree of deformity between two groups.
Results ① Lysholm score and VAS score: There was no significant difference between the two groups before treatment (t = 0.020.099, P > 0.05), but after treatment, the ZN group had higher Lysholm score and lower VAS score (P<0.05); ② C-reactive protein and uric acid: There was no significant difference between the two groups of patients before treatment (P>0.05), and the ZN group was even lower after treatment (P<0.05); ③ Knee joint range of motion, pain index, and degree of deformity: Before treatment, there was no significant difference between the two groups of patients (P>0.05). After treatment, the ZN group of patients had higher knee joint range of motion, lower pain index, and degree of deformity score (P<0.05).
Conclusion   In the treatment of patients with acute gouty arthritis of damp heat obstruction type, the use of self-designed Quzhuo Huayu San external treatment intervention can effectively improve knee joint function, reduce pain levels, improve inflammatory factor levels, enhance knee joint mobility, and reduce joint deformities. It is worth promoting and implementing.