摘要
二甲双胍作为2型糖尿病的一线药物被广泛应用于临床，近年来其临床价值不断被发掘，国内外学者研究发现，二甲双胍除其明显的降血糖作用外，还具有抗炎、抗氧化应激、抗细胞凋亡、调节细胞自噬、调控免疫、抗肿瘤等作用，其适应症也不断延展，如辅助治疗多囊卵巢综合征、非酒精性脂肪肝等疾病，并对脓毒症心肌损害具有潜在治疗价值，但是其作用机制仍有待进一步阐明。鉴于此，为开拓治疗脓毒症心肌损害的新思路，本研究收集近年来的相关文献，就二甲双胍在脓毒症的心肌损伤发生过程中具有的抗炎、抗氧化应激、抗凋亡、调节细胞自噬四个方面进行综述，以探索二甲双胍对脓毒症心肌损伤的独特作用机制。
关键词： 二甲双胍；脓毒症；心肌损伤；抗炎作用；抗氧化应激；抗凋亡；细胞自噬；研究进展
Abstract
As a first-line drug for type 2 diabetes mellitus, metformin has been widely used in clinic, and its clinical value has been continuously explored in recent years. Domestic and foreign scholars have found that metformin has anti-inflammatory, antioxidant stress, anti-apoptosis, autophagy regulation, immune regulation and anti-tumor effects in addition to lowering blood glucose, and its indications are also constantly expanding, Such as adjuvant treatment of polycystic ovary syndrome, non-alcoholic fatty liver and other diseases. Additionally, it holds potential therapeutic value for sepsis-induced myocardial injury; however, the precise mechanism of action still requires further elucidation. In view of this, in order to explore new ideas for the treatment of sepsis induced myocardial injury, this study collected relevant literature in recent years and reviewed the anti-inflammatory, anti-oxidative stress, and anti-apoptotic effects, regulating cellular autophagy of metformin in the process of sepsis induced myocardial injury, in order to explore the unique mechanism of metformin's action on sepsis induced myocardial injury.
Key words： Metformin; Sepsis; Myocardial injury; Anti-inflammatory effect; Anti-oxidative stress; Anti-apoptotic; Autophagy; The research progress
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