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当前位置：国际临床研究杂志 > 2024年 8卷 (1)期

Open Access Article

International Journal of Clinical Research. 2024; 8: (1) ; 22-26 ; DOI: 10.12208/j.ijcr.20240006.

Research progress on the correlation between CYP19A1 gene single nucleotide polymorphismand growth hormone
CYP19A1基因单核苷酸多态性多态性与生长激素相关性研究进展

作者： 王环溪, 王爱萍 *

昆明市第一人民医院云南昆明

*通讯作者：王爱萍,单位：昆明市第一人民医院云南昆明；

发布时间: 2024-01-20 总浏览量: 184

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摘要

CYP19A1基因编码着重要的酶——芳香化酶，该酶属于雌激素合成过程中的关键酶。CYP19A1基因的变异可以使其编码的芳香化酶活性发生改变，从而影响雌激素的水平，近年来CYP19A1基因的单核苷酸多态性已成为研究关注的热点问题之一。生长激素在人类生长和发育过程中起着重要作用，因生长激素完全或部分缺乏所导致的生长激素缺乏症作为影响儿童身高、导致儿童矮小的常见内分泌疾病，其发病率在我国逐年攀升，现已有研究表明CYP19A1基因SNPs与身高变异及生长激素水平之间存在关联，本文将就当前各方面研究结果，对CYP19A1基因多态性与生长激素相关性的研究进展进行综述。

关键词： CYP19A1基因；单核苷酸多态性；生长激素

Abstract

CYP19A1 gene encodes an important enzyme - aromatase, which is a key enzyme in the process of estrogen synthesis. The variation of the CYP19A1 gene can change the aromatase activity encoded by it, thus affecting the level of estrogen. In recent years, the single nucleotide polymorphism of the CYP19A1 gene has become one of the hot issues in research. Growth hormones play an important role in human growth and development. Growth hormone deficiency caused by complete or partial lack of growth hormone is a common endocrine disease that affects children's height and leads to children's shortness. Its incidence is increasing year by year in China. Studies have shown that CYP19A1 gene SNP There is a correlation between height variation and growth hormone levels. This article will review the research progress of the correlation between CYP19A1 gene polymorphism and growth hormone based on the current research results.

Key words： CYP19A1 gene; Single nucleotide polymorphism; Growth hormones

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引用本文

王环溪, 王爱萍, CYP19A1基因单核苷酸多态性多态性与生长激素相关性研究进展[J]. 国际临床研究杂志, 2024; 8: (1) : 22-26.

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