摘要
近年来结直肠癌已是全球第三大常见的癌症。结肠癌起病常较隐匿，早期临床表现常不明显，绝大多数患者就诊时已处于肿瘤晚期。癌症干细胞（CSC）以前在多种类型的癌症中发现，结肠癌就是其中之一，它与几种生物标志物相关。与结直肠相关的两个最重要的标志物是 CD44 和 CD133。结肠癌患者的上皮细胞中Septin9的转录本就过表达。本文将从Septin9与CD44在结肠癌中的表达及其临床意义进行阐述。
关键词： 结肠癌；Septin9；CD44；肿瘤干细胞
Abstract
In recent years, colorectal cancer has become the third most common cancer worldwide. The onset of colon cancer is often insidious, the early clinical manifestations are often not obvious, and the vast majority of patients have been in the advanced stage of cancer. Cancer stem cells (CSC) have previously been found in many types of cancer, colon cancer being one of them, and are associated with several biomarkers. The two most important markers associated with colorectal cancer are CD44 and CD133. Septin9 transcripts are overexpressed in epithelial cells of patients with colon cancer. This article will discuss the expression of Septin9 and CD44 in colon cancer and their clinical significance.
Key words： Colon cancer; Septin9; CD44; Tumor stem cell
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