CSCIED

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Clinical Research. 2023; 7: (12) ; 16-20 ; DOI: 10.12208/j.ijcr.20230359.

The significance and mechanism of uterine artery parameters in RSA etiology screening
子宫动脉参数在RSA病因筛查中的意义及作用机制

作者: 孟昱君1, 王英兰2 *

1 暨南大学 深圳

2 深圳市人民医院 深圳

*通讯作者: 王英兰,单位: 深圳市人民医院 深圳;

发布时间: 2023-12-28 总浏览量: 384

摘要

复发性流产(recurrent spontaneous abortion,RSA)是妊娠期间发生连续三次及以上的自发性流产,严重影响了妇女的生育健康和心理状态。原发性复发性流产的病因尚不明确,但对于未知病因的RSA患者,尽早的干预进行有效治疗是至关重要的。近年来,发现子宫动脉血流异常与RSA之间存在密切联系,引起了广泛关注。子宫动脉参数可以通过无创的彩超技术进行预测和指导RSA患者。子宫动脉各项参数,如血流速度、阻力指数等,能够反映子宫血流情况及其供血功能。通过对这些参数的研究与分析,可以揭示RSA发病机制,并为RSA患者的诊断与治疗提供有力支持。本文讲述RSA患者的子宫动脉参数的临床意义以及其作用机制。

关键词: 子宫动脉;复发性流产;超声多普勒

Abstract

Recurrent spontaneous abortion (RSA) is a type of spontaneous abortion that occurs three or more times in a row during pregnancy, seriously affecting women's reproductive health and psychological state. The etiology of primary recurrent miscarriage is not yet clear, but for RSA patients with unknown etiology, early intervention and effective treatment are crucial. In recent years, it has been found that there is a close relationship between abnormal uterine artery blood flow and RSA, which has attracted widespread attention. Uterine artery parameters can be predicted and guided by non-invasive ultrasound technology for RSA patients. Various parameters of the uterine artery, such as blood flow velocity, resistance index, etc., can reflect the uterine blood flow situation and its blood supply function. By studying and analyzing these parameters, the pathogenesis of RSA can be revealed, providing strong support for the diagnosis and treatment of RSA patients. This article discusses the clinical significance and mechanism of action of uterine artery parameters in RSA patients.

Key words: Uterine artery; Recurrent miscarriage; Ultrasound Doppler

参考文献 References

[1] 俞晓晶,王芳. 复发性流产的病因研究[J]. 医学信息,2020,33(10):34-36.

[2] 葛逸盟, 杨硕, 李蓉. 子宫内膜容受性评价方法及其临床应用的研究进展 [J]. 中国微创外科杂志, 2023, 23(09): 686-92.

[3] YOUNG S L. Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity [J]. Reprod Biomed Online, 2013, 27(5): 497-505.

[4] 潘臧钰, 王国云. 子宫内膜容受性临床表现和检测方法的研究进展 [J]. 中国计划生育和妇产科, 2023, 15(05): 16-21.

[5] 强嘉璘. 超声检测复发性流产患者子宫动脉血流频谱波形特征和血流动力学参数的临床价值 [J]. 中国妇幼保健, 2021, (08): 1823-5.

[6] 张小亮, 郑兴亚, 王悦, et al. 经阴道彩色多普勒超声对早孕期先兆流产的诊断及预后评估价值 [J]. 影像研究与医学应用, 2018, (14): 177-80.

[7] 廖文靖. 彩色多普勒检测子宫动脉联合血清胎盘生长因子预测复发性流产的相关性研究 [D]; 济宁医学院, 2020.

[8] 邹淑伟, 韩彦峰, 吴秀英. 彩色多普勒超声及内膜微血管密度在反复自然流产患者子宫内膜容受性评价中的应用[J]. 中国医药导报, 2018, (14): 54-7.

[9] 李雪梅, 易蕾, 陆鸣鸣. 复发性流产与子宫动脉血流动力学的关系研究[J]. 右江民族医学院学报, 2017,( 06): 481-484.

[10] 姚庆荣, 陈达丽, 杨芃, et al. 子宫动脉血流频谱波形及搏动指数评估复发性自然流产[J]. 中国医学影像技术, 2021, (04): 620-622.

[11] 方建红, 张淑红, 梁金丽. 复发性流产患者与正常孕妇子宫动脉血流参数的比较[J]. 医学综述, 2016, (21): 4357-4359.

[12] KANG X, WANG T, HE L, et al. Effect of Low-Dose Aspirin on Midluteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss [J]. J Ultrasound Med, 2016, 35(12): 2583-2587.

[13] 李焕菊, 崔德宝. 绒毛滋养动脉血流指标对孕早期先兆流产孕妇保胎治疗的预测价值 [J]. 中国计划生育学杂志, 2018, (01): 46-49.

[14] LAZZARIN N, VAQUERO E, EXACOUSTOS C, et al. Midluteal phase Doppler assessment of uterine artery blood flow in nonpregnant women having a history of recurrent spontaneous abortions: correlation to different etiologies [J]. Fertil Steril, 2007, 87(6): 1383-1387.

[15] DETTI L, JOHNSON S C, DIAMOND M P, et al. First-trimester Doppler investigation of the uterine circulation [J]. Am J Obstet Gynecol, 2006, 195(5): 1210-1218.

[16] ZHANG K, WANG E, LI Y, et al. Role of low-molecular-weight heparin in altering uterine artery blood flow in recurrent spontaneous abortion: a prospective study [J]. J Int Med Res, 2020, 48(8): 300060520945558.

[17] Goswamy RK, Williams G, Steptoe PC. Decreased uterine perfusion--a cause of infertility[J]. Hum Reprod, 1988 ,3(8): 955-959. 

[18] TOHMA H, HASEGAWA I, SEKIZUKA N, et al. Uterine blood flow. Assessment in an intrauterine insemination program for unexplained infertility [J]. J Reprod Med, 1997, 42(8): 463-466.

[19] OU H, YU Q. Efficacy of aspirin, prednisone, and multivitamin triple therapy in treating unexplained recurrent spontaneous abortion: A cohort study [J]. Int J Gynaecol Obstet, 2020, 148(1): 21-26.

[20] 谷嫦娟, 王晓云, 晁岚. 早孕期子宫动脉血流参数与复发性流产的相关性 [J]. 西部医学, 2020, (05): 680-3+6.

[21] MESDAGHINIA E, MOHAMMAD-EBRAHIMI B, FOROOZANFARD F, et al. The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial [J]. Int J Reprod Biomed, 2017, 15(10): 635-640.

[22] VARUGHESE E E, BRAR P S, DHINDSA S S. Uterine blood flow during various stages of pregnancy in dairy buffaloes using transrectal Doppler ultrasonography [J]. Anim Reprod Sci, 2013, 140(1-2): 34-39.

[23] 耿旭娜. 经阴道彩色多普勒超声对胎停育的子宫动脉血流动力学变化研究 [D]; 河北医科大学, 2016.

[24] 边莹, 骆军英, 朱桂清, et al. 早孕期孕妇子宫动脉血流参数与早期自然流产的相关性研究 [J]. 实用医技杂志, 2018, (02): 138-139.

[25] 程军, 范瑾, 吴爱华, et al. 超声在复发性自然流产女性中对子宫内膜的诊断效果及血流动力学研究 [J]. 中国社区医师, 2016, (30): 130-131.

[26] 陈清爽, 苏新辉, 冉静, et al. 不同病因的复发性流产患者妊娠期子宫动脉血流变化及其临床意义 [J]. 中国现代医药杂志, 2021, 23(10): 16-21.

[27] BROSENS I, PUTTEMANS P, BENAGIANO G. Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes [J]. Am J Obstet Gynecol, 2019, 221(5): 437-456.

[28] WINDSPERGER K, DEKAN S, PILS S, et al. Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions [J]. Hum Reprod, 2017, 32(6): 1208-1217.

[29] Son JB, Jeong JE, Joo JK, et al. Measurement of endometrial and uterine vascularity by transvaginal ultrasonography in predicting pregnancy outcome during frozen-thawed embryo transfer cycles[J]. J Obstet Gynaecol Res, 2014 ,40(6):1661-1667. 

[30] Dempsey MA, Flood K, Burke N, et al. Platelet function in patients with a history of unexplained recurrent miscarriage who subsequently miscarry again[J]. Eur J Obstet Gynecol Reprod Biol, 2015 ,188:61-65. 

[31] 程亚丽,吴媛,刘辉. 不孕症与复发性流产患者宫腔病变性质宫腔镜检查的比较[J]. 中国妇幼保健,2021,36(8): 1817-1819.

引用本文

孟昱君, 王英兰, 子宫动脉参数在RSA病因筛查中的意义及作用机制[J]. 国际临床研究杂志, 2023; 7: (12) : 16-20.