摘要
近几年来，由于宫颈癌筛查的普遍应用以及HPV疫苗的预防接种，使得宫颈癌前病变及部分宫颈癌早发现早治疗，但其发病率及死亡率仍未见明显下降，且发病率愈来愈趋向年轻化。脆性组氨酸三联体（FHIT）、p16基因在多瘤种中均有表达。本文针对宫颈癌患者中FHIT、p16的表达情况进行综述。
关键词： 宫颈癌；脆性组氨酸三联体（FHIT）；p16；组织；表达
Abstract
In recent years, due to the widespread application of cervical cancer screening and HPV vaccine vaccination, cervical precancerous lesions and some cervical cancers have been found and treated early, but their incidence rate and mortality have not decreased significantly, and the incidence rate is becoming younger and younger. Fragile histidine triad (FHIT) and p16 genes are expressed in multiple tumor species. This article reviews the expression of FHIT and p16 in cervical cancer patients.
Key words： Cervical cancer; Fragile histidine triad; p16; Organization; Expression
参考文献 References
[1] 刘宗超,李哲轩,张阳,等.2020全球癌症统计报告解读[J].肿瘤综合治疗电子杂志,2021,(02):1-14.
[2] Waters CE, Saldivar JC, Hosseini SA,et. The FHIT gene product: tumor suppressor and genome "caretaker". Cell Mol Life Sci. 2014 Dec;71(23):4577-87.
[3] Kujan O, Abuderman A, Al-Shawaf AZ. Immunohisto chemical characterization of FHIT expression in normal human tissues. Interv Med Appl Sci. 2016 Mar;8(1):7-13.
[4] 董仙萍,王健,杨冬梅等.宫颈上皮内瘤变及宫颈癌组织中DLC-1、BMI-1、C-myc、FHIT的表达及意义[J].山东医药, 2018,58(14):75-78.
[5] 张茹,孙爱芹,曲华清.FHIT蛋白和Ki67在子宫颈癌中的表达及临床意义[J].中国医药指南, 2016,14(15):31+33.
[6] 卢建军,张微,李响等.宫颈癌并发人乳头瘤病毒感染癌症组织FHIT和C-myc研究[J].中华医院感染学杂志,2019,29(21):3293-3297.
[7] Wu MZ, Wang S, Zheng M, et. The Diagnostic Utility of p16 Immunostaining in Differentiating Cancer and HSIL from LSIL and Benign in Cervical Cells. Cell Transplant. 2019 Feb;28(2):195-200.
[8] 晁远,李美波,宋安辉.P16蛋白在宫颈癌和宫颈上皮内瘤变中的表达及临床意义[J].基层医学论坛,2023,27(01): 81-83.
[9] 杨弋弋,周新欢,邹科等.KISS-1、P16和SCC-Ag在宫颈癌组织中的表达及意义[J].实用癌症杂志,2022,37(10): 1578-1582.
[10] Song F, Du H, Xiao A,et. Evaluating the Performance of p16INK4a Immunocytochemistry in Cervical Cancer Screening. Cancer Manag Res. 2020 Sep 25;12:9067-9075.