Clinical observation on radiotherapy for cervical cancer patients with autoimmune diseases
宫颈癌合并自身免疫性疾病患者放射治疗的临床观察

摘要

目的 通过对宫颈癌合并自身免疫性疾病患者进行分析，随后采用放射治疗方式，探究效果。方法参与本次研究的患者就诊时间在2021年1月到12月，共计患者21例，开展放疗毒性反应、免疫功能变化的分析。结果 通过分析21例患者放疗毒性反应发生情况可知，在急性血液毒性反应中Ⅲ-Ⅳ级患者占据28.6%，其中5例出现血液学毒性，1例出现消化系统毒性以及1例泌尿系统毒性，分别占据23.8%、4.8%、4.8%。其中2例患者发生慢性消化毒性反应，占据9.55%,1例慢性泌尿毒性反应，占比4.8%。对21例患者在治疗前后外周血T细胞亚群进行对比可知，在治疗前CD4+为37.96±10.44，治疗后为35.46±9.17，其中治疗前CD8+为25.45±5.13，治疗后改变为26.00±4.86，CD4+/CD8+治疗前为1.52±0.40，治疗后为1.39±0.39，差异无统计学意义（p>0.05）。结论 采用放射治疗对于宫颈癌合并自身免疫性疾病患者耐受性尚可，针对具有放疗适应症患者需开展规范化治疗方式。

Abstract

Objective To analyze patients with cervical cancer combined with autoimmune diseases and then explore the effectiveness of radiation therapy.
Methods The patients participating in this study visited from January to December 2021, with a total of 21 patients undergoing analysis of radiation toxicity and immune function changes.
Results By analyzing the occurrence of radiation toxicity reactions in 21 patients, it can be seen that 28.6% of patients with grade III-IV acute blood toxicity reactions, including 5 cases with hematological toxicity, 1 case with digestive system toxicity, and 1 case with urinary system toxicity, accounting for 23.8%, 4.8%, and 4.8%, respectively. Two patients experienced chronic digestive toxicity reactions, accounting for 9.55%, and one patient experienced chronic urinary toxicity reactions, accounting for 4.8%. Comparing the peripheral blood T cell subpopulations of 21 patients before and after treatment, it was found that CD4+was 37.96 ± 10.44 before treatment and 35.46 ± 9.17 after treatment. Among them, CD8+was 25.45 ± 5.13 before treatment, changed to 26.00 ± 4.86 after treatment, and CD4+/CD8+was 1.52 ± 0.40 before treatment and 1.39 ± 0.39 after treatment, with no statistically significant difference (p>0.05).
Conclusion   The use of radiation therapy is tolerable for patients with cervical cancer and autoimmune diseases, and standardized treatment methods should be carried out for patients with radiation indications.