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Open Access Article

International Journal of Clinical Research. 2023; 7: (9) ; 8-11 ; DOI: 10.12208/j.ijcr.20230311.

Research Progress in targeted therapy for advanced NSCLC with KRAS mutation
KRAS突变晚期NSCLC靶向治疗研究进展

作者: 薛彩花, 韩舒 *, 李鹏涛, 陈士花, 刘巧玲, 刘洪训

黄岛区中心医院肿瘤科 山东青岛

*通讯作者: 韩舒,单位:黄岛区中心医院肿瘤科 山东青岛;

发布时间: 2023-09-30 总浏览量: 339

摘要

肺癌是世界上常见的癌症死亡原因之一,大约85%的肺癌是非小细胞肺癌(non-small cell lung cancer, NSCLC)[1]。KRAS突变在NSCLC驱动基因突变中较为常见[2]。既往针对KRAS突变的NSCLC患者多选择无驱动基因的方案治疗。近年来随着对KRAS突变NSCLC生物学特征的深入研究,KRAS抑制剂临床实验也取得突破性进展[3]。现对KRAS突变晚期NSCLC靶向治疗研究进展作一综述。

关键词: 非小细胞肺癌;KRAS突变;抑制剂

Abstract

Lung cancer is one of the most common causes of cancer death in the world, with approximately 85% of lung cancers being non-small cell lung cancer, NSCLC)[1]. KRAS mutation is relatively common among NSCLC driver gene mutations[2]. In the past, NSCLC patients with KRAS mutation were treated with a non-driver gene regimen. In recent years, with the in-depth research on the biological characteristics of KRAS mutant NSCLC, breakthrough progress has been made in KRAS inhibitor clinical trials[3]. This article reviews the progress of targeted therapy for advanced NSCLC with KRAS mutation.

Key words: Non-small cell lung cancer, NSCLC; KRAS mutation; Inhibitor

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引用本文

薛彩花, 韩舒, 李鹏涛, 陈士花, 刘巧玲, 刘洪训, KRAS突变晚期NSCLC靶向治疗研究进展[J]. 国际临床研究杂志, 2023; 7: (9) : 8-11.