CSCIED

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Clinical Research. 2023; 7: (8) ; 93-95 ; DOI: 10.12208/j.ijcr.20230308.

Research progress on pharmacological effects of liquiritin
甘草苷的药理作用研究进展

作者: 刘金霞1, 董玉玲1, 陈保华2 *

1 甘肃泛植制药有限公司 甘肃兰州

2 兰州大学化学化工学院 甘肃兰州

*通讯作者: 陈保华,单位: 兰州大学化学化工学院 甘肃兰州;

发布时间: 2023-08-21 总浏览量: 582

摘要

甘草是我国重要的中药材之一,广泛应用于医药、食品等行业。甘草苷为其主要黄酮类成分之一,具有抗氧化、抗炎、抗菌、抗抑郁、抗癌、保肝、保护心血管等多种药理活性,具有广阔的应用前景。

关键词: 甘草;甘草苷;抗炎;抗菌;药理作用

Abstract

Licorice is one of the important Chinese medicinal materials in China, widely used in medicine, food and other industries. Liquiritin is one of the main flavonoids, which has many pharmacological activities such as antioxidant, anti-inflammatory, antibacterial, anti-depression, anticancer, liver protection, cardiovascular protection, etc., and has broad application prospects.

Key words: Licorice; Liquiritin; Anti-inflammatory; Antibacterial; Pharmacological effects

参考文献 References

[1] Yang X, Dang X, Zhang X, et al. Liquiritin reduces lipopolysaccharide-aroused HaCaT cell inflammation damage via regulation of microRNA-31/MyD88. Int Immunopharmacol. 2021, 101 (Pt B): 108283. 

[2] LIN H, HU J, MEI F, et al. Anti-microbial efficacy, mechanisms and druggability evaluation of the natural flavonoids. J Appl Microbiol. 2022 Jul 8. 

[3] LIU P, CAI Y, ZHANG J, et al. Antifungal activity of liquiritin in Phytophthora capsici comprises not only membrane-damage-mediated autophagy, apoptosis, and Ca2+ reduction but also an induced defense responses in pepper. Ecotoxicol Environ Saf. 2021, 209:111813. 

[4] LIU C, YUAN D, ZHANG C, et al. Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus. Evid Based Complement Alternat Med. 2022,11; 2022: 7558825. 

[5] AIYASIDING X, LIAO HH, FENG H, et al. Liquiritin Attenuates Pathological Cardiac Hypertrophy by Activating the PKA/LKB1/AMPK Pathway. Front Pharmacol. 2022, 13: 870699. 

[6] WANG Q, WEI C, WENG W, et al. Enhancement of oral bioavailability and hypoglycemic activity of liquiritin -loaded precursor liposome. Int J Pharm. 2021, 592: 120036.

[7] YUAN L, WANG D, WU C. Protective effect of liquiritin on coronary heart disease through regulating the proliferation of human vascular smooth muscle cells via upregulation of sirtuin1. Bioengineered. 2022, 13(2): 2840-2850. 

[8] LI Y, XIA C, YAO G, et al. Protective effects of liquiritin on UVB-induced skin damage in SD rats. Int Immunopharmacol. 2021, 97: 107614.

[9] MOU SQ, ZhOU ZY, FENG H, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021, 12: 648688.

[10] Mo J, Zhou P, Chu Z, et al. Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway. Evid Based Complement Alternat Med. 2022 Mar 16;2022:7861338. 

[11] Huang Z, Sheng Y, Chen M, et al. Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system. Toxicol Appl Pharmacol. 2018 Sep 15;355:18-27. 

[12] 国家药典委员会.中华人民共和国药典:一部[S]. 北京:中国医药科技出版社,2020:155-168.

[13] 杨倩倩,孟子盈,王晓禹等.甘草苷的提取纯化和药理作用研究进展[J].中国野生植物资源,2023,42(04):12-17.

[14] 蒋英彩, 韩毓, 韦先梅, 等. 甘草苷对妊娠糖尿病大鼠胰岛素抵抗及Ras/Raf-1/ERK信号通路的影响[J].

[15] 中国优生与遗传杂志, 2021, 29 (10) : 1373-1377.

[16] 刘萌. 甘草苷调控SLC7A11/GPX4信号通路预防阿霉素心脏毒性的机制研究[D].南华大学,2022.

[17] 曲欣妮,李文标,王利等.基于网络药理学及实验验证探讨甘草苷治疗帕金森病的作用机制[J/OL].世界科学技术-中医药现代化:1-13[2023-08-19].

引用本文

刘金霞, 董玉玲, 陈保华, 甘草苷的药理作用研究进展[J]. 国际临床研究杂志, 2023; 7: (8) : 93-95.