Effect of simvastatin combined with aspirin in the treatment of cerebral thrombusand its effect on neurological impairment
辛伐他汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响

摘要

目的 为提高脑血栓患者治疗效果、改善其神经功能缺损程度，本文着重探讨了辛伐他汀联合阿司匹林药物的临床应用价值。方法 此次实验共选取112例脑血栓患者进行对比实验，采取盲抽方式进行分组，对照组与观察组各56例患者，前者在治疗时给予阿司匹林药物，后者在此基础上联合辛伐他汀药物，对两组临床效果进行比较。结果 经实验结果来看，相比对照组，观察组整体治疗效果较高；治疗前两组患者IMT与斑块面积数据基本无差异（P＞0.05），但治疗后观察组斑块面积、颈动脉内膜中层厚度等指标数值均低于对照组（P＜0.05）；与此同时对比两组治疗前后NIHSS评分以及Barthel指数分别呈现出（P＞0.05）、（P＜0.05），治疗前评估差异无统计学意义，而治疗后观察组神经功能缺损程度评分以及日常生活能力评分明显低于对照组及治疗前。结论 对脑血栓患者而言，在治疗时给予辛伐他汀联合阿司匹林不仅能够有效减轻神经功能缺损程度，更可最大程度地减少与降低颈动脉斑块面积以及厚度，切实提升其日常生活能力，治疗效果较优。

Abstract

Objective In order to improve the therapeutic effect of cerebral thrombosis and improve the degree of neurological impairment, the clinical application value of simvastatin combined with aspirin was discussed.
Methods A total of 112 patients with cerebral thrombosis were selected for comparative experiment and divided into groups by blind sampling. 56 patients in each control group and observation group were given aspirin during treatment, while the latter combined with simvastatin on this basis, and the clinical effects of the two groups were compared.
Results Compared with the control group, the overall therapeutic effect of the observation group was higher. Before treatment, there was no difference in IMT and plaque area between the two groups (P > 0.05), but after treatment, the plaque area and carotid intima-media thickness in the observation group were lower than those in the control group (P < 0.05). At the same time, the NIHSS score and Barthel index before and after treatment were compared between the two groups (P > 0.05) and (P < 0.05), respectively, and there was no statistical significance in the assessment before treatment. After treatment, the score of neurological impairment and the score of daily living ability in the observation group were significantly lower than those in the control group and before treatment.
Conclusion   For patients with cerebral thrombosis, simvastatin combined with aspirin during treatment can not only effectively reduce the degree of neurological impairment, but also reduce the area and thickness of carotid artery plaque to the greatest extent, effectively improve their daily life ability, and the therapeutic effect is better.