摘要
MCP-1（单核细胞化学引诱蛋白-1），也称为趋化因子（CC-motif）配体2（CCL2），来自CC趋化因子家族。它在炎症发生发展过程中起着重要的作用，它可产生或增强其他炎症因子/细胞的表达。它通过诱导炎症细胞（如单核细胞/巨噬细胞和其他细胞因子）向炎症部位的迁移和浸润的主要机制导致许多疾病的发生发展。MCP-1已被直接或间接地归咎于许多疾病的发病机制，如心血管疾病、呼吸系统疾病、神经炎症性疾病等。本综述将侧重于MCP-1在各种疾病病理中的参与和作用。
关键词： 趋化因子；炎症；疾病病理；作用
Abstract
MCP-1 (monocyte chemoattractant protein-1), also known as chemokine (CC-motif) ligand 2 (CCL2), comes from the CC chemokine family. It plays an important role in the development of inflammation, which can produce or enhance the expression of other inflammatory factors/cells. It leads to the development of many diseases through the main mechanism of inducing the migration and infiltration of inflammatory cells (such as monocytes/macrophages and other cytokines) to the site of inflammation. MCP-1 has been directly or indirectly attributed to the pathogenesis of many diseases, such as cardiovascular diseases, respiratory diseases, neuroinflammatory diseases, etc. This review will focus on the involvement and role of MCP-1 in the pathology of various diseases.
Key words： Chemokines; Inflammation; Disease pathology; Role
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