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Open Access Article

International Journal of Clinical Research. 2023; 7: (7) ; 43-45 ; DOI: 10.12208/j.ijcr.20230273.

Research progress of Ulcerative colitis
溃疡性结肠炎研究进展

作者: 底星, 陈刚 *

佳木斯大学附属第一医院 黑龙江佳木斯

*通讯作者: 陈刚,单位:佳木斯大学附属第一医院 黑龙江佳木斯;

发布时间: 2023-07-15 总浏览量: 215

摘要

溃疡性结肠炎(UC)是一种慢性特发性肠炎,可引起从直肠到更近端结肠的持续粘膜炎症,程度不一。UC的特点是复发和缓解过程[1]。虽然UC的病因仍有争议,但越来越多的证据表明UC与遗传学,免疫力及环境因素有明显的相关性,一些研究报告UC与幽门螺杆菌胃炎或局灶性胃炎有关,随着溃疡性结肠炎患者数量的增多,对UC病因,早期诊断及治疗显的尤为重要,本文从现代医角度分别对溃疡性结肠炎的病因,诊断和治疗方法进行阐述。

关键词: 溃疡性结肠炎;内镜检查;治疗

Abstract

Ulcerative colitis (UC) is a chronic idiopathic enteritis that can cause persistent mucosal inflammation from the rectum to the proximal colon to varying degrees. The characteristic of UC is the process of recurrence and remission [1]. Although the etiology of UC is still controversial, more and more evidence shows that UC is obviously related to genetics, immunity and environmental factors. Some studies report that UC is related to Helicobacter pylori gastritis or focal gastritis. With the increase of the number of patients with Ulcerative colitis, early diagnosis and treatment of UC are particularly important. This article describes the etiology, diagnosis and treatment of Ulcerative colitis from the perspective of modern medicine.

Key words: Ulcerative colitis; Endoscopic examination; Treatment

参考文献 References

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[2] Liu J Z, van Sommeren S, Huang H, et al. Association analyses identify 38 susceptibility loci for inflammatory bowel  disease and highlight shared genetic risk across populations[J]. Nat Genet, 2015,47(9):979-986.

[3] Jostins L, Ripke S, Weersma R K, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory  bowel disease[J]. Nature, 2012,491(7422): 119 -124.

[4] Chen G B, Lee S H, Brion M J, et al. Estimation and partitioning of (co)heritability of inflammatory bowel disease  from GWAS and immunochip data[J]. Hum Mol Genet, 2014, 23(17): 4710-4720.

[5] Chen Z, O'Shea J J. Th17 cells: a new fate for differentiating helper T cells[J]. Immunol Res, 2008,41(2): 87 -102.

引用本文

底星, 陈刚, 溃疡性结肠炎研究进展[J]. 国际临床研究杂志, 2023; 7: (7) : 43-45.