Clinical Observation on the Treatment of Rheumatoid Arthritis with Duhuo Parasitic Decoction and MTX
独活寄生汤联合MTX治疗类风湿关节炎临床观察

摘要

目的 探讨独活寄生汤联合MTX治疗类风湿关节炎的临床疗效。方法 选择60例类风湿关节炎患者为研究对象，将其随机分为观察组与对照组各30例患者。对照组患者选择MTX口服治疗的方法。观察组患者在对照组的基础上搭配独活寄生汤治疗。观察两组患者在治疗前后晨僵时间，关节压痛、肿胀指数以及治疗前后TNF-α、IL-6、C反应蛋白（CRP）、红细胞沉降率（ESR）的变化情况。结果 观察组治疗的临床总有效率显著高于对照组，两组患者在治疗后的晨僵、压痛、肿胀指数比治疗前明显降低，且观察组患者比对照组患者相应指标改善的情况更加明显，对于TNF-α、IL-6、CRP、ESR指标，观察组下降情况显著高于对照组（P均<0.05）。结论 独活寄生汤联合MTX治疗类风湿关节炎的总有效率较高，临床疗效较好。

Abstract

Objective: To explore the clinical efficacy of Duhuo parasitic decoction combined with MTX in the treatment of rheumatoid arthritis.
Methods 60 patients with rheumatoid arthritis were selected as the study subjects and randomly divided into an observation group and a control group with 30 patients each. Patients in the control group chose MTX oral treatment. Patients in the observation group were treated with Duhuo Parasitic Decoction on the basis of the control group. Observe the morning stiffness time, joint tenderness, swelling index, and TNF before and after treatment in both groups of patients- α, Changes in IL-6, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).
Results The total clinical effective rate of treatment in the observation group was significantly higher than that in the control group. After treatment, the morning stiffness, tenderness, and swelling index of patients in the two groups were significantly lower than before treatment, and the improvement of corresponding indicators in the observation group was more significant than that in the control group. For TNF- α, The decrease of IL-6, CRP, ESR in the observation group was significantly higher than that in the control group (P<0.05).
Conclusion  : The total effective rate of Duhuo parasitic decoction combined with MTX in the treatment of rheumatoid arthritis is high, and the clinical efficacy is good.