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当前位置：国际临床研究杂志 > 2023年 7卷 (5)期

Open Access Article

International Journal of Clinical Research. 2023; 7: (5) ; 1-5 ; DOI: 10.12208/j.ijcr.20230201.

The levels and clinical significance of serum LAMP- 2 in patients with polyarteritis nodosa
LAMP-2在结节性多动脉炎中的表达水平及临床意义

作者： 朱晴, 洪静, 朱彬, 吴婷, 刘莎莎, 李南方 *

新疆维吾尔自治区人民医院高血压中心新疆乌鲁木齐

新疆高血压研究所新疆乌鲁木齐

国家卫生健康委高血压诊疗研究重点实验室新疆乌鲁木齐

新疆维吾尔自治区重点实验室“新疆高血压病研究实验室” 新疆乌鲁木齐

新疆高血压（心脑血管）疾病临床医学研究中心新疆乌鲁木齐

*通讯作者：李南方,单位：新疆维吾尔自治区人民医院高血压中心新疆乌鲁木齐；

新疆维吾尔自治区自然科学基金资助项目（2019D01C105）

发布时间: 2023-05-13 总浏览量: 278

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摘要

目的探讨血清溶酶体相关膜蛋白2（LAMP-2）在结节性多动脉炎（PAN）患者中的表达及其临床意义。方法本研究共纳入26例PAN患者作为病例组。同期收集与之性别、年龄相匹配的健康体检者26例作为对照（HC）组。根据伯明翰血管炎活动期评分（BVAS）量表对PAN的疾病活动程度进行评估。采用ELISA检测所有研究对象血清中LAMP-2水平。结果 PAN患者血清LAMP-2水平显著高于HC，差异有显著统计学意义 [0.66 (0.49-2.95) vs 0.17 (0.10-0.32)，Z=4.813，P<0.001]。相关性分析表明，血清LAMP-2水平与BAVS（r=0.438，P=0.025）、Hs-CRP（r=0.592，P=0.001）和ESR（r=0.406，P=0.039）呈显著正相关，而与Scr（r=0.198，P=0.332）以及24小时蛋白尿（r=0.225，P=0.302）无相关性。结论与对照组相比，PAN患者的血清LAMP-2水平升高，且与疾病活动指标呈正相关。LAMP-2可能是一种新型的生物标记物用于PAN患者的诊断及疾病活动评估。

关键词： 溶酶体相关膜蛋白2；结节性多动脉炎；疾病活动

Abstract

Objective: To investigate the levels and clinical significance of serum lysosome-associated membrane protein-2 (LAMP-2) in patients with polyarteritis nodosa (PAN).
Methods A total of 26 PAN patients were enrolled as case group. At the same time, 26 healthy persons matched with sex and age were collected as health controls (HC) group.The disease activity of PAN was assessed by the birmingham vasculitis activityscore (BVAS). The level of LAMP-2 in serum of all subjects was detected by ELISA.
Results The level of serum LAMP-2 in PAN patients was significantly higher than in HC, the difference was statistically significant [0.66 (0.49-2.95) vs 0.17 (0.10-0.32), Z = 4.813, P < 0.001]. The correlation analysis showed that serum LAMP-2 levels were positively correlated with BAVS (r=0.438, P=0.025), Hs-CRP (r=0.592, P=0.001) and ESR (r=0.406, P=0.039), but not with Scr (r=0.198, P=0.332) and 24-hour proteinuria (r=0.225, P=0.302).
Conclusion Compared with the control group, the serum LAMP-2 level of PAN patients was increased, which was positively correlated with disease activity indicators. LAMP-2 May be a novel biomarker for diagnosis and disease activity assessment of PAN patients.

Key words： Lysosome-associated membrane protein 2; Polyarteritis nodosa; Disease activity

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引用本文

朱晴, 洪静, 朱彬, 吴婷, 刘莎莎, 李南方, LAMP-2在结节性多动脉炎中的表达水平及临床意义[J]. 国际临床研究杂志, 2023; 7: (5) : 1-5.

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