Effect of platelet-derived growth factor on peripheral nerve regeneration of implants in rats
血小板衍生生长因子对大鼠种植体周围神经再生影响分析

摘要

目的 分析血小板衍生生长因子（PDGF）影响大鼠种植体周边神经再生的情况。方法 构建大鼠股骨植入种植体模型，在刚开始愈合阶段进行PDGF的连续注射，经由免疫组化（IHC）染色技术对PDGF影响种植体周边神经再生的状况展开分析。结果 在PDGF作用下，大鼠股骨种植体周边初期神经纤维数量有所增多，但是未发现其显著影响到后期种植体周边的神经纤维数目。此外，此类神经具备周围神经（PN）纤维的典型结构。结论 对于种植体周边初期神经再生，PDGF表现出有效地促进作用。此项研究为实现PDGF增强种植体周边神经再生，由此使得种植体感觉功能得到有效改善的临床应用，在实验层面上给予一定指导。

Abstract

Objective: To analyze the effect of platelet-derived growth factor (PDGF) on peripheral nerve regeneration in rats.
Methods: A rat model of femoral implant was established. PDGF was injected continuously at the beginning of healing. The effect of PDGF on peripheral nerve regeneration was analyzed by immunohistochemistry (IHC) staining.
Results: Under the action of PDGF, the number of nerve fibers around the femoral implant in rats increased at the initial stage, but it was not found that it significantly affected the number of nerve fibers around the implant at the later stage. In addition, these nerves have typical structures of peripheral nerve (PN) fibers.
Conclusion  : PDGF can effectively promote the peripheral nerve regeneration of implants. In order to realize the clinical application of PDGF to enhance peripheral nerve regeneration of implants, so as to effectively improve the sensory function of implants, this study provides some guidance at the experimental level.