Efficacy of recombinant human erythropoietin on anemia in patients undergoing lung cancer chemotherapy
重组人促红细胞生成素对肺癌化疗患者贫血的疗效观察

摘要

目的 分析肺癌化疗患者的贫血的原因，探讨重组人促红细胞生成素应用于肺癌化疗患者后疗效及不良反应。方法 采用我院HIS系统收集我院2020年5月—2022年4月两年间，通过临床和病理确诊为肺癌患者并且接受化疗的40例患者，年龄在40岁—75之间，分为二组，实验组（N=20）和对照组（N=20），均接受3个周期化疗，化疗期间出现贫血均给予铁剂治疗。实验组在每个化疗周期结束后5小时在给予铁剂治疗的基础上给予皮下注射重组人促红细胞生成素10000IU，每周注射三次，连续注射4周。对比分析两组患者的治疗效果。结果 注射重组人促红细胞生成素患者血红蛋白、红细胞、红细胞比容三项指标改善明显优于未注射组（P<0.05）。在注射重组人促红细胞生成素4周内，随着治疗时间的延长，贫血改变越明显。结论 重组人促红细胞生成素治疗化疗期间出现的贫血有一定疗效，同时需注意用药时的不良反应，及时进行监测处理。

Abstract

Objective: To analyze the causes of anemia in lung cancer chemotherapy patients and explore the efficacy and adverse reactions of recombinant human erythropoietin applied to lung cancer chemotherapy patients. Method: Our hospital's HIS system was used to collect 40 lung cancer patients who were clinically and pathologically diagnosed with lung cancer and underwent chemotherapy from May 2020 to April 2022, aged between 40 and 75 years old. They were divided into two groups: the experimental group (N=20) and the control group (N=20), both receiving three cycles of chemotherapy. Anemia during the chemotherapy period was treated with iron. The experimental group received subcutaneous injection of 10000 IU of recombinant human erythropoietin 5 hours after the end of each chemotherapy cycle, in addition to iron therapy, three times a week for 4 consecutive weeks. The treatment effects of the two groups of patients were compared and analyzed.
Results The improvement of hemoglobin, red blood cell and hematocrit in patients injected with recombinant human erythropoietin was significantly better than that in patients without injection（P<0.05）. Within 4 weeks of injection of recombinant human erythropoietin, the anemia changes become more pronounced with the prolongation of treatment time.
Conclusion  : Recombinant human erythropoietin has a certain therapeutic effect on anemia during chemotherapy, and attention should be paid to adverse reactions during medication, and timely monitoring and treatment should be carried out.