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Open Access Article

International Journal of Clinical Research. 2023; 7: (4) ; 143-146 ; DOI: 10.12208/j.ijcr.20230191.

Clinical efficacy of flunarizine hydrochloride in the treatment of migraine
盐酸氟桂利嗪治疗偏头痛的临床疗效

作者: 张伟 *

鹤壁市人民医院 河南鹤壁

*通讯作者: 张伟,单位:鹤壁市人民医院 河南鹤壁;

发布时间: 2023-04-13 总浏览量: 335

摘要

目的 探讨在偏头痛治疗中采用盐酸氟桂利嗪的临床效果。方法 选取2022年1月到2022年12月我院收治的90例偏头痛患者,随机分成对照组(n=45,尼麦角林片)与研究组(n=45,盐酸氟桂利嗪),对比偏头痛相关症状及疼痛评分、血清指标、血流动力学指标、不良反应发生率、生活质量评分。结果 研究组偏头痛发作次数、发作持续时间、疼痛评分均较少,P<0.05;研究组TNF-α、ICAM-1、CGRP、IL-1β均较低,5-HT较高,P<0.05;研究组血流动力学指标较低,P<0.05;两组不良反应发生率无显著差异,P>0.05;研究组生活质量评分较高,P<0.05。结论 在偏头痛治疗中采取盐酸氟桂利嗪效果确切,改善血流动力学,缓解偏头痛症状,提高生活质量。

关键词: 偏头痛;盐酸氟桂利嗪;血流动力学;疼痛;生活质量

Abstract

Objective: To explore the clinical effect of flunarizine hydrochloride in the treatment of migraine.
Methods: A total of 90 patients with migraine admitted to our hospital from January 2022 to December 2022 were randomly divided into a control group (n=45, nimergoline tablets) and a study group (n=45, flunarizine hydrochloride). The migraine-related symptoms and pain scores, serum indicators, hemodynamic indicators, incidence of adverse reactions, and quality of life scores were compared.
Results: The frequency, duration, and pain score of migraine attacks in the study group were less (P<0.05); Research group TNF- α、 ICAM-1、CGRP、IL-1 β Both were lower, with a higher 5-HT, P<0.05; The hemodynamic indexes in the study group were lower (P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05); The quality of life score in the study group was higher (P<0.05).
Conclusion  : Flunarizine hydrochloride is effective in the treatment of migraine, improving hemodynamics, alleviating migraine symptoms, and improving quality of life.

Key words: Migraine; Flunarizine hydrochloride; Hemodynamics; Pain; Quality of life

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引用本文

张伟, 盐酸氟桂利嗪治疗偏头痛的临床疗效[J]. 国际临床研究杂志, 2023; 7: (4) : 143-146.