Changes and clinical significance of serum pepsinogen and gastrin 17 levels in patients with chronic atrophic gastritis
慢性萎缩性胃炎患者血清胃蛋白酶原、胃泌素17水平的变化及其临床意义

摘要

目的 通过观察慢性萎缩性胃炎患者血清胃蛋白酶原、胃泌素17水平的变化情况，研究其临床意义。方法 纳入2020年5月-2022年5月在本院接受胃镜检查的200例患者为研究对象，根据检查结果分为健康组（未见任何异常，n＝60）、实验1组（慢性萎缩性胃炎，n＝73）、实验2组（慢性非萎缩性胃炎，n＝67），分别测量三组的血清胃蛋白酶原Ⅰ、Ⅱ和胃泌素17水平，并根据萎缩部位的不同进行分组，比较各组间的胃蛋白酶原和胃泌素17水平。结果 实验1组的胃蛋白酶原Ⅰ、Ⅱ水平低于健康组和实验2组，胃泌素17水平高于健康组和实验2组，胃蛋白酶原Ⅰ与胃蛋白酶原Ⅱ比值（PGR）低于健康组和实验2组，均有统计学意义（P＜0.05）。结论 慢性萎缩性胃炎患者的血清胃蛋白酶原、胃泌素17水平与正常人之间有较大差异，及时进行筛查有助于临床确诊，同时明确萎缩部位。

Abstract

Objective: To study the clinical significance of chronic atrophic gastritis by observing the changes of serum pepsinogen and gastrin 17 levels.
Methods: 200 patients who received gastroscopy in our hospital from May 2020 to May 2022 were enrolled as the study subjects. According to the results, they were divided into healthy group (no abnormality, n=60), experimental group 1 (chronic atrophic gastritis, n=73), and experimental group 2 (chronic nonaatrophic gastritis, n=67). The serum pepsinogen I, II and gastrin 17 levels in the three groups were measured respectively, and were grouped according to the different atrophic sites, The levels of pepsinogen and gastrin 17 were compared among the groups.
Results: The levels of pepsinogen I and II in experimental group 1 were lower than those in healthy group and experimental group 2, the levels of gastrin 17 were higher than those in healthy group and experimental group 2, and the ratio of pepsinogen I to pepsinogen II (PGR) was lower than those in healthy group and experimental group 2, with statistical significance (P<0.05).
Conclusion  : The levels of serum pepsinogen and gastrin 17 in patients with chronic atrophic gastritis are significantly different from those in normal people. Timely screening is helpful for clinical diagnosis and identification of atrophic sites.