Efficacy analysis of large dose omeprazole in the treatment of senile gastric ulcer complicated with bleeding
大剂量奥美拉唑治疗老年胃溃疡合并出血的疗效分析

摘要

目的 分析在对老年胃溃疡合并出血患者治疗期间选用大剂量奥美拉唑施治的效果。方法 入组研究的100例对象均筛选自我院消化内科2019年1月到2020年1月间收治并确诊的胃溃疡合并出血老年患者，按照治疗期间奥美拉唑的使用剂量不同分组，将常规剂量治疗的50例划入对照组，将大剂量治疗的50例划入观察组。对两组疗效相关指标进行对比分析。结果 观察组治疗总有效率高于对照组，主要症状（如呕血用时等）消失用时均短于对照组，且1个月内复发率低于对照组，组间上述指标对比结果均有差异性出现，P＜0.05。在不良反应发生率方面无组间对比差异，P＞0.05。结论 大剂量奥美拉唑治疗老年胃溃疡合并出血效果显著。

Abstract

Objectives To analyze the effect of large-dose omeprazole in the treatment of elderly patients with gastric ulcer and bleeding.
Methods: the 100 subjects enrolled in the study were all elderly patients with gastric ulcer and bleeding who were admitted and diagnosed in the Department of Gastroenterology of our hospital from January 2019 to January 2020. They were divided into groups according to the dosage of omeprazole used during the treatment period. 50 cases of routine dose treatment were assigned to the control group, and 50 cases of high-dose treatment were assigned to the observation group. The related indexes of the two groups were compared and analyzed.
Results: the total effective rate of the observation group was higher than that of the control group, the time for disappearance of main symptoms (such as hematemesis) was shorter than that of the control group, and the recurrence rate within one month was lower than that of the control group. There were differences in the comparison results of the above indicators between the groups (P < 0.05). There was no difference in the incidence of adverse reactions between groups (P > 0.05).
Conclusion  : high dose omeprazole is effective in treating senile gastric ulcer with bleeding.