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Open Access Article

International Journal of Clinical Research. 2023; 7: (1) ; 51-55 ; DOI: 10.12208/j.ijcr.20230015.

Serum Homocysteine and folate level and their relationship with P300 and psychotic symptoms in first-episode schizophrenia patients
首发精神分裂症患者血清同型半胱氨酸、叶酸水平与P300及精神症状的关系

作者: 王定祥, 王祖森, 张晶蓓, 宋传福, 康海燕, 杨涛, 王小泉 *

安徽省芜湖市第四人民医院 安徽芜湖

*通讯作者: 王小泉,单位:安徽省芜湖市第四人民医院 安徽芜湖;

发布时间: 2023-01-29 总浏览量: 373

摘要

目的 探讨首发精神分裂症患者(FES)血清同型半胱氨酸(Homocysteine, Hcy)、叶酸水平与事件相关电位P300及精神症状之间的关系。方法 分别采用酶法和电化学发光法测试91例FES患者及95例正常对照者的血清同型半胱氨酸和叶酸水平,对所有受试者进行了事件相关电位P300检测;并对结果进行比较和分析。结果 FES组血清Hcy水平明显高于正常对照组(P<0.01),血清叶酸水平显著低于对照组(P<0.05);和对照组相比,FES组P300中P3波幅明显降低(P<0.01),潜伏期明显延长(P<0.01)。相关分析显示,血清Hcy水平与PANSS各分量表及总分均无相关(P>0.05);血清Hcy水平与血清叶酸水平相关无统计学意义(P>0.05);血清叶酸水平与P3波幅及潜伏期相关均无统计学意义(P>0.05);血清叶酸水平与PANSS量表各项评分无相关(P>0.05);PANSS阳性、阴性症状量表评分与P3波幅及潜伏期相关均无统计学意义(P>0.05),一般病理分与波幅成负相关(P<0.05)。结论 FES患者血清Hcy、叶酸水平异常,与认知功能的损害无直接关联;FES患者精神症状严重程度与认知功能受损有关。

关键词: 精神分裂症;同型半胱氨酸;叶酸;P300;精神症状

Abstract

Objective: To research the levels of serum homocyteine(Hcy)and folate and their relationship with P300 and psychotic symptoms in first-episode schizophrenia(FES) patients.
Methods: The levels of serum Hcy and folate in 91 FES patients and 95 normal controls were tested by Enzymatic Method and electrochemical luminescence method respectively. All subjects completed auditory evoked event-related potential P300 test. Furthermore, they completed mental symptoms assessments by Positive and Negative Syndrome Scale (PANSS) assessments. The results were compared and analyzed.
Results: The serum level of Hcy in schizophrenia group was significantly higher than in control group (P<0.01). And the serum level of folate in schizophrenia group was lower than in control group(P<0.05).Compared with control group, the auditory evoked event-related potentials P300 latency period was significanty prolonged, and the amplitude was significanty decreased (all P< 0. 01). Pearson’s correlation analysis indicated that the serum Hcy level was not related to the serum folate level and the score of PANSS and the latencies and aplitudes of P300 in FES patients (P>0.05), and the score of the general psychopathological scale was negatively relevant to the aplitude of P300 in FES patients (P<0.05).
Conclusion  : The level of serum Hcy elevated while serum level of folate decreased in FES, and the serum Hcy and folate had not direct correlation with cognition. Both have some relevance with the severity of mental symptom and cognitive dysfunction.

Key words: Schizophrenia; Homocysteine; Folate; P300; Psychotic Symptoms

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引用本文

王定祥, 王祖森, 张晶蓓, 宋传福, 康海燕, 杨涛, 王小泉, 首发精神分裂症患者血清同型半胱氨酸、叶酸水平与P300及精神症状的关系[J]. 国际临床研究杂志, 2023; 7: (1) : 51-55.