摘要
目的 研究实时二维剪切波弹性成像技术在评估乙肝病毒携带者抗病毒治疗启动时机及治疗效果的临床应用价值。方法 选取2019年1月至2021年5月期间在清远市人民医院就诊的68例乙型肝炎病毒携带患者作为研究对象，分治疗组和对照组。结果 治疗组2D-SWE测得肝硬度值（LSM）分别为9.03士0.24 kPa和7.55士0.26 kPa；P <0.001，具有统计学意义；对照组LSM分别为8.34士0.18 kPa和6.94士0.26 kPa；P <0.001，具有统计学意义；两组患者LSM在48周时均较入组时下降。48周时治疗组有83.33%的患者HBVDNA低于检测下限（20IU/ml）。结论 通过实时二维剪切波弹性成像技术测量乙型肝炎病毒携带者的肝硬度值，有助于确定开始抗毒治疗的时机，具有极高的临床应用价值。
关键词： 乙肝病毒携带者；实时二维剪切波弹性成像；抗病毒治疗
Abstract
Objective: science and technology plan of Qingyuan City, Guangdong Province (1909101548681)
[Abstract] Objective To study the clinical application value of real-time two-dimensional shear wave elastography in evaluating the starting time and therapeutic effect of antiviral therapy for hepatitis B virus carriers. Methods 68 patients with hepatitis B virus in Qingyuan people's Hospital from January 2019 to may 2021 were selected as the research objects, and were divided into treatment group and control group. Results the liver hardness (LSM) measured by 2d-swe in the treatment group were 9.03 ± 0.24 kPa and 7.55 ± 0.26 kPa respectively; P <0.001, with statistical significance; LSM of control group was 8.34 ± 0.18 kPa and 6.94 ± 0.26 kPa respectively; P <0.001, with statistical significance; LSM in both groups decreased at 48 weeks compared with that at enrollment. At 48 weeks, 83.33% of patients in the treatment group had HBVDNA lower than the lower limit of detection (20iu/ml). Conclusion the measurement of liver hardness of hepatitis B virus carriers by real-time two-dimensional shear wave elastography is helpful to determine the timing of anti-virus treatment, and has high clinical application value.
Key words： Hepatitis B Virus Carriers; Real Time Two-Dimensional Shear Wave Elastography; Antiviral Therapy
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