摘要
近来载脂蛋白E（Apo-E）受到广泛关注。随着分子生物学的应用和研究的深入，有学者提出载脂蛋白E在妊娠期高血压疾病患者，尤其是子痫前期患者中存在异常表达。本文就载脂蛋白E(Apo E)表达在妊娠期高血压疾病中的研究现状及进展进行分析，以探讨载脂蛋白E的异常表达对妊娠期高血压疾病的预测及发病的影响，为妊娠期高血压疾病的早期预防及诊治提供指导作用。
关键词： 载脂蛋白E；妊娠期高血压疾病；分子生物学
Abstract
Recently, apolipoprotein E(Apo-E) has received extensive attention. With the deepening of the application and research of molecular biology, some scholars have proposed that Apo E has abnormal expression in patients with hypertensive disorder complicating pregnancy, especially in patients with preeclampsia. This paper analyzed the research status and progress of Apo E expression in hypertensive disorder complicating pregnancy, to explore the impact of abnormal Apo E expression on the prediction and incidence of hypertensive disorder complicating pregnancy, so as to provide guidance for the early prevention, treatment and diagnosis of hypertensive disorder complicating pregnancy.
Key words： Apolipoprotein E; Hypertension in Pregnancy; Molecular Biology
参考文献 References
[1] 中华医学会妇产科学分会妊娠期高血压疾病学组. 妊娠期高血压疾病诊治指南(2020)[J]. 中华妇产科杂志, 2020, 55(04): 227-238.
[2] 毕万达, 刘阳珷玥, 戴双双. 载脂蛋白E在创伤性脑损伤中作用及机制的研究进展[J]. 中华神经创伤外科电子杂志, 2022, 8(01): 51-55.
[3] 杜鹤峣. 化验单上的载脂蛋白是什么意思[J]. 家庭医药.就医选药, 2021(12): 67.
[4] 解吉雄, 王锐, 戴颖, 等. 巨细胞病毒及肺炎支原体感染和载脂蛋白E基因多态性与脑梗死患者颈动脉粥样硬化的关联[J]. 中华医院感染学杂志, 2022(11): 1673-1677.
[5] 陈磊, 刘新灿, 王炜, 等. 急性心肌梗死患者血清N末端脑钠肽前体、载脂蛋白E、载脂蛋白A1、载脂蛋白B水平与冠状动脉病变的关系探究[J]. 中国临床医生杂志, 2022, 50(05): 550-554.
[6] Wang J, Shan S, Lyu A, et al. A novel model of myocardial infarction based on atherosclerosis in mice[J]. Biochem Biophys Res Commun, 2021, 576: 100-107.
[7] Rebeck G W. The role of APOE on lipid homeostasis and inflammation in normal brains[J]. J Lipid Res, 2017, 58(8): 1493-1499.
[8] Kemp S B, Carpenter E S, Steele N G, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1[J]. Cancer Res, 2021, 81(16): 4305-4318.
[9] 魏晓慧, 高丽萍, 武双红. 载脂蛋白E与肿瘤发生的关系研究[J]. 解放军医药杂志, 2016, 28(01): 49-52.
[10] Innes H, Nischalke H D, Guha I N, et al. The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis[J]. Hepatol Commun, 2022, 6(5): 1213-1226.
[11] Liu H, Sun Y, Zhang Q, et al. Pro-inflammatory and proliferative microglia drive progression of glioblastoma [J]. Cell Rep, 2021, 36(11): 109718.
[12] Zhao Z, Zou S, Guan X, et al. Apolipoprotein E Overexpression Is Associated With Tumor Progression and Poor Survival in Colorectal Cancer[J]. Front Genet, 2018, 9: 650.
[13] 张春利, 岳建宏. 妊娠期高血压疾病患者血清低密度脂蛋白 载脂蛋白E水平变化及意义[J]. 山西医药杂志, 2021, 50(01): 40-41.
[14] 李璐, 高玉洁. 子痫前期产妇脂联素、前列腺素E2、孕酮、皮质醇和载脂蛋白的测定及意义[J]. 黑龙江医学, 2015, 39(04): 364-367.
[15] 李磊, 孔倩倩, 钮威, 等. 载脂蛋白E等位基因多态性对徐州地区高血压患者的影响[J]. 检验医学与临床, 2021, 18(16): 2332-2334.
[16] 李秀明, 季加芬, 刘长云, 等. 妊娠期代谢综合征对母儿脂代谢的影响研究[J]. 中国当代医药, 2018, 25(17): 87-89.