Study on the relationship between brain natriuretic peptide level and acute myocardial infarction area
脑钠肽水平与急性心肌梗死面积关系的探究

摘要

目的 分析脑钠肽（BNP）水平与急性心肌梗死面积关系，旨在更好的推测心肌梗死的病变程度，判断预后。方法 选取我院近2年（2019年8月-2021年9月）接受经皮冠状动脉介入治疗的急性心肌梗死患者45例作为观察组，选取同期健康体检者40例作为对照组。利用ELISA法对两组患者的BNP含量进行测定，并运用心肌梗死损伤积分法观察两组患者的心肌梗死面积，分析BNP水平与心肌梗死面积的关系，以此判定预后。结果 入院时，观察组、对照组患者BNP水平分别为（308.52±124.39）ng/L、（25.66±10.21）ng/L，可知观察组BNP水平明显高于对照组，差异有统计学意义（P<0.05）。入院7d后，观察组、对照组患者BNP水平分别为（146.87±72.53）ng/L、（25.41±10.68）ng/L，可知观察组BNP水平较入院时有明显降低，但仍明显高于对照组，差异有统计学意义（P<0.05）；在观察组患者中，前壁心肌梗死者BNP水平（327.24±72.95）ng/L、心肌梗死面积（166.73±51.24）%均高于下壁心肌梗死者的（296.41±69.17）ng/L、（156.03±53.66）%，组间对比差异无统计学意义（P>0.05）；对急性心肌梗死患者BNP水平与心肌梗死面积相关性分析，运用线性回归分析显示，心肌梗死面积越大，BNP含量越高，呈正相关，差异有统计学意义（P<0.05）。结论 急性心肌梗死者急性期BNP水平显著升高，尽管梗死部位与BNP水平无关，但前壁心肌梗死预后较差。笔者认为BNP可作为预测急性心肌梗死患者预后的敏感指标之一；急性心肌梗死者BNP水平与梗死面积相关，呈正相关。

Abstract

Objective: To analyze the relationship between brain natriuretic peptide (BNP) level and acute myocardial infarction area, in order to better predict the degree of myocardial infarction and judge the prognosis.
Methods: 45 patients with acute myocardial infarction who received percutaneous coronary intervention in our hospital in recent 2 years (August 2019 September 2021) were selected as the observation group, and 40 healthy people in the same period were selected as the control group. The BNP content of the two groups of patients was measured by ELISA, and the myocardial infarction area of the two groups was observed by myocardial infarction injury integral method, and the relationship between BNP level and myocardial infarction area was analyzed to determine the prognosis.
Results: at admission, the BNP levels of patients in the observation group and the control group were (308.52 ± 124.39) ng/l and (25.66 ± 10.21) ng/l respectively. It can be seen that the BNP level of the observation group was significantly higher than that of the control group, and the difference was statistically significant (p<0.05). Seven days after admission, the BNP levels in the observation group and the control group were (146.87 ± 72.53) ng/l and (25.41 ± 10.68) ng/l respectively. It can be seen that the BNP level in the observation group was significantly lower than that in the admission group, but it was still significantly higher than that in the control group, and the difference was statistically significant (p<0.05); In the observation group, BNP level (327.24 ± 72.95) ng/l and myocardial infarction area (166.73 ± 51.24)% in patients with anterior myocardial infarction were higher than those with inferior myocardial infarction (296.41 ± 69.17) ng/l and (156.03 ± 53.66)% respectively. There was no significant difference between the groups (p>0.05); The correlation analysis between BNP level and myocardial infarction area in patients with acute myocardial infarction showed that the larger the myocardial infarction area, the higher the BNP content, which was positively correlated, and the difference was statistically significant (p<0.05).
Conclusion  : BNP level in patients with acute myocardial infarction is significantly increased in the acute phase. Although the infarct location has nothing to do with BNP level, the prognosis of anterior myocardial infarction is poor. The author believes that BNP can be used as one of the sensitive indicators to predict the prognosis of patients with acute myocardial infarction; BNP level was positively correlated with infarct size in patients with acute myocardial infarction.