摘要
侵袭性肺曲霉病主要发生于免疫功能低下的患者。伏立康唑属于第二代三唑类抗真菌药物具有较强的抗菌效果，对曲霉菌具有较好的抗菌活性，在侵袭性肺曲霉病治疗中发挥着重要的作用。侵袭性肺曲霉病患者体内存在明显的炎症反应，同时因为免疫功能低下免疫因子水平发生改变，局部侵袭性肺曲霉病中的慢性空洞性肺曲霉病若未得到治疗可引起肺纤维化。为进一步探究、总结伏立康唑用于治疗侵袭性肺曲霉病的肺抗菌性作用，可从对细胞因子及肺纤维的影响进行分析。
关键词： 伏立康唑；侵袭性肺曲霉病；细胞因子；肺纤维化
Abstract
Invasive pulmonary aspergillosis mainly occurs in immunocompromised patients. Voriconazole is a second-generation triazole antifungal drug with strong antibacterial effect and good antibacterial activity against Aspergillus, which plays an important role in the treatment of invasive pulmonary aspergillosis. Patients with invasive pulmonary aspergillosis have obvious inflammatory responses, and because of the altered levels of immune factors in the immunocompromised, chronic cavitary pulmonary aspergillosis in local invasive pulmonary aspergillosis can cause pulmonary fibrosis if left untreated. To further explore and summarize the pulmonary antibacterial effect of voriconazole in the treatment of invasive pulmonary aspergillosis, the effects on cytokines and pulmonary fibers can be analyzed.
Key words： Voriconazole; Invasive Pulmonary Aspergillosis; Cytokines; Pulmonary Fibrosis
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